Abstract: Objective To explore the clinical features and pathological changes in patients with drug-induced liver injury（DILI） in recent years. Methods Data of 441 patients with DILI from January 2010 to May 2014,including the medication courses,clinical manifestations, lab results,pathological findings and disease courses, were retrospectively analyzed. Results The numbers of patients with traditional Chinese medicine（TCM）-induced liver injury and western medicine-induced liver injury were 176 （39.91%） and 210 （47.62%）,respectively;All patients were divided into three clinical types:e.g. 178（40.36%） with hepatocyte DILI,132（29.93%） with cholestatic DILI and 131（29.71%） with mixed DILI;No significant difference was found in histological changes and laboratory indexes between TCM-and western medicine-induced liver injuries（P>0.05）;However,TCM-induced patients had a lower incidences of erythra than in patients receiving western medicine（1.1% vs. 5.2%,P<0.05）,but had a higher incidences of splenomegaly（78.4% vs. 46.2%,P<0.05）;In addition,it took longer to develop liver injuries for TCM-induced patients（P<0.05）;The recovery rate of all the DILI patients in this series was 94.56%. Conclusion A variety of medicines is closely involved in reducing DILI in clinical practice,which warrants further studies.

Key words: Drug-induced liver injury, Clinical feature, Histological change