酒精性肝病患者血清IL-33高水平的临床意义*

doi:10.3969/j.issn.1672-5069.2015.02.012

Abstract

Abstract: Objective To explore the changes of serum IL-33 levels in patients with alcoholic liver diseases. Methods Serum levels of IL-33 and its soluble receptor sST2 in patients with alcoholic hepatitis（n=40）, severe alcoholic hepatitis（n=17）,alcoholic liver cirrhosis（n=75）,and healthy individuals （n=20） were measured by ELISA. IL-33 and sST2 levels in different groups were compared and the correlation between serum IL-33 levels and the regular biochemical indexes was analyzed. Results Patients with alcoholic hepatitis,severe alcoholic hepatitis and cirrhosis had elevated serum IL-33 levels than that in the controls[（85.20±9.44） pg/ml,（68.70±8.14） pg/ml,（64.45±3.78） pg/ml vs. （42.17±2.41） pg/ml,P<0.001 for all],while IL-33 in patients with alcoholic hepatitis were significantly higher than that in cirrhotic patients（P<0.05）;however,there was no statistical difference between patients with severe hepatitis and cirrhosis with different Child-Pugh class;Serum sST2 in alcoholic hepatitis,severe alcoholic hepatitis and cirrhosis group significantly elevated compared to that in the controls [（96.75±11.30） pg/ml,（51.92±11.78） pg/ml,（75.82±6.81） pg/ml vs. （43.97±3.01） pg/ml,P<0.001 for all],while serum sST2 levels in patients with alcoholic hepatitis was higher than that in patients with severe hepatitis or cirrhosis（P<0.001 and P<0.05,respectively）;in addition,serum sST2 in patients with alcoholic cirrhosis with Child-Pugh A class was significantly higher than those in cirrhotic patients with Child-Pugh B class or C class（P<0.001 for both）;there was no correlation between serum IL-33 and sST2（R=0.100,P=0.180）;Serum IL-33 levels in patients with alcoholic liver disease showed positive correlation with lymphocyte counts（R=0.273,P<0.01）,ALB（R=0.237,P<0.01）,ALT（R=0.462,P<0.001）,AST（R=0.387,P<0.001）and CHE（R=0.225,P<0.01）,while no significant correlation with neutrophils,TBIL,ALP,GGT,TC and PTA. Conclusion Elevated serum IL-33 levels might contribute to the development of alcoholic liver disease by aggravating immunological reaction.

Key words: Alcoholic liver diseases, Interleukin-33, SolubleST2, Clinical index

Hao Shuli, Zhang Jiyuan, Huang Ang, et al.. Clinical significance of increased serum IL-33 levels in patients with alcoholic liver diseases[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2015, 18(2): 156-159.

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Clinical significance of increased serum IL-33 levels in patients with alcoholic liver diseases

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