右美托咪定复合丙泊酚靶控输注处理ERCP治疗胆总管结石患者麻醉效果研究*

doi:10.3969/j.issn.1672-5069.2026.05.033

Abstract

Abstract: Objective The aim of this study was to investigate sedation of dexmedetomidine and propofol combination for target-controlled infusion (TCI) in patients with common bile duct stones (CBDS) undergoing endoscopic retrograde cholangiopancreatography (ERCP). Methods 102 patients with CBDS were encountered in our hospital between January 2023 and May 2025, and they all underwent selective ERCP. For sedation, they were randomly divided into control (n=51) and observation group (n=51), receiving sufentanil and propofol combination for TCI or dexmedetomidine and propofol combination for TCI, respectively. Anesthesia time, recovery time and anesthesia recovery time were recorded. Heart rate (HR), mean arterial pressure (MAP) and oxygen saturation (SpO₂) were monitored by a monitor at time of entering operating room (T₀), induction completion (T₁), endoscope insertion (T₂), 10 min after endoscope insertion (T₃), discontinuation of drug administration (T₄) and at 5 min after entering the recovery room (T₅). Ramsay sedation scale (RSS) score was evaluated, and visual analogue scale (VAS) was used to evaluate pain. Plasma cortisol (Cor), adrenocorticotropic hormone (ACTH) and tumor necrosis factor-α (TNF-α) levels were detected by ELISA. Results At T₂ to T₅, HR and MAP in the observation group were significantly lower than in the control group (P<0.05), and at T₁ to T₄, the RSS scores in the observation group were significantly higher than in the control group (P<0.05); after surgery, serum Cor, ACTH and TNF-α levels in the observation group were (228.6±34.6) mmol/L, (18.5±3.6) pmol/L and (30.1±3.5) pg/mL, all significantly lower than [(269.0±33.9) mmol/L, (25.4±4.3) pmol/L and (41.8±5.9) pg/mL, respectively, P<0.05) in the control group. Conclusion TCI by dexmedetomidine in combination with propofol has a satisfactory sedation in patients with CBDS undergoing ERCP, which might relieve postoperative body stress.

Key words: Common bile duct stones, Endoscopic retrograde cholangiopancreatography, Dexmedetomidine, Propofol, Target-controlled infusion, Sedation

Tao Qiaojian, Zhong Huagen, Pan Hongxi. Sedation of dexmedetomidine and propofol combination for target-controlled infusion in patients with common bile duct stones undergoing ERCP[J]. Journal of Practical Hepatology, 2026, 29(5): 769-772.

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Sedation of dexmedetomidine and propofol combination for target-controlled infusion in patients with common bile duct stones undergoing ERCP

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