Abstract: Objective The aim of this study was to explore the evaluation of liver fibrosis by ultrasound elastography(UE) and serum liver fibrosis indexes in patients with schistosomiasis liver disease (SILD). Methods A total of 98 patients with SILD were admitted to our hospital between October 2022 and September 2025, and all underwent liver biopsies. Liver stiffness measurement (LSM) was detected by UE, and shear wave velocity (SWV) was obtained. Serum hyaluronic acid (HA), laminin (LN), IV collagen (IV-C) and III procollagen (PCIII) levels were assayed by ELISA. Diagnostic efficacy for severity of liver fibrosis was evaluated by receiver operating characteristic (ROC) curves. Results Of 98 patients with SILD, liver histopathological examination found significant liver fibrosis (SLF) in 62 cases (63.3%)and non-SLF (NSLF) in 36 cases (36.7%); LSM and SWV in SLF group were (12.2±3.7)kPa and (1.7±0.4)m/s, both much greater than [(6.9±1.1)kPa and (1.2±0.3)m/s, respectively P＜0.05] in NSLF group; serum HA and Ⅳ-C levels in SLF group were (287.3±92.8)ng/mL and (191.6±34.4)ng/mL,both much higher than [(144.7±18.4)ng/mL and (82.3±15.2)ng/mL,respectively, P＜0.05] in NSLF group; ROC analysis showed that AUC(0.962), sensitivity (95.2%) and specificity (86.1%) were all met request of clinical diagnosis for SLF. Conclusion The diagnostic efficacy of UE parameters in combination with serum liver fibrosis indexes is good for screening of liver fibrosis in patients with SILD, which warrants further clinical investigation.

Key words: Schistosomiasis liver disease, Liver fibrosis, Ultrasound elastography, Liver stiffness measurement, Shear wave velocity, Diagnosis