Abstract: Objective The aim of this study was to observe analgesic efficacy of ultrasound (US)-guided costotransverse block in patients with cholelithiasis undergoing laparoscopic cholecystectomy (LC). Methods A total of 126 patients with gallbladder stones were encountered in our hospital between January 2024 and June 2025, and all underwent LC with general anesthesia. For post-operational analgesia, the patients were randomly assigned to receive paravertebral block (n=62) in control, or receive US-guided costotransverse block (n=62) in observation. Visual analogue scale (VAS) scores in resting and motion states were recorded. Results The extubation time, PACU stay, and recovery time after anesthesia in the observation group were(12.4±1.6)min, (35.7±4.2)min and (10.1±1.9)min, all much shorter than [(15.3±1.7)min, (41.8±6.4)min and (13.6±2.1)min, respectively, P<0.05], and total dosage of intraoperative sufentanil administration and 24-hour total dosage of postoperative opioids were(18.7±2.4)μg and (24.7±3.6)mg, both significantly less than [(25.7±3.5)μg and (38.3±4.2)mg, respectively, P<0.05] in the control group; by 8 hour and 24 hour after operation, resting VAS scores in the observation group were (2.2±0.3) and (2.8±0.2), both much lower than [(2.9±0.3) and (4.1±0.5), P<0.05], and motion VAS scores were (3.8±0.5) and (4.5±0.6), both much lower than [(4.8±0.5) and (5.4±0.6), P<0.05] in the control group; by T1 and T4, heart beats and average blood pressure were much slower or lower than in the control group (P＜0.05). Conclusion US-guided costotransverse block in patients after LC exhibits a satisfactory analgesic efficacy, with minimal impact on cardiovascular hemodynamics.

Key words: Cholelithiasis, Laparoscopic cholecystectomy, Ultrasound-guidance, Costotransverse block, Analgesia