Abstract: Objective The aim of this study was to evaluate analgesic effect of fluorobiphenyl ester and fentanyl hydrochloride combination in patients with cholecystolithiasis during laparoscopic cholecystectomy (LC). Methods A total of 104 patients with cholecystolithiasis were encountered in our hospital between April 2022 and November 2024, and all underwent LC. For analgesia, the patients were assigned to receive propofol and sufentanil hydrochloride in 52 cases in control group, or to receive propofol, flurbiprofen axetil and sufentanil hydrochloride combination in other 52 cases in the observation group. Hemodynamic parameters, e.g., heart rate (HR) and mean arterial pressure (MAP) were monitored before anesthesia induction (T0), after loss of consciousness (T1), after skin incision (T2), after extubation (T3) and 10 minutes post-extubation (T4). Postoperative pain was assessed by using the visual analog scale (VAS) at 2 h, 6 h, 12 h and 24 h. Recovery times for spontaneous breathing and awakening were recorded. Serum levels of interleukin-1β (IL-1β), IL-6 and IL-10 were measured by ELISA. Results In combination group, it showed significantly lower HRs and MAPs at T1 to T4 compared to in the control group (P<0.05); recovery times for spontaneous breathing [(8.6±2.5) min] and awakening [(9.1±2.9) min] were much shorter in the combination group than in the control group [(10.9±2.9) min and (12.7±3.0) min, respectively, P<0.05]; postoperative VAS scores at 2 h, 6 h and 12 h were also much lower in the combination group [(1.9±0.5), (2.1±0.7) and (2.9±0.8) points] compared to in the control group [(2.2±0.5), (3.1±0.9) and (3.9±1.1) points, P<0.05]; at 12 hours postoperatively, serum levels of IL-1β and IL-6 in the combination group were (43.5±8.0)pg/mL and (107.1±18.6)pg/mL, both significantly lower than [(49.1±7.5)pg/mL and (126.3±14.6)pg/mL, respectively, P＜0.05] in the control group. Conclusion The combination of sufentanil hydrochloride and flurbiprofen axetil provides an effective postoperative analgesia in patients with cholecystolithiasis during LC, with relatively less impact on hemodynamic parameters and quick consciousness, which might be related to less activation of cytokine reaction.

Key words: Cholecystolithiasis, Laparoscopic cholecystectomy, Sufentanil hydrochloride, Flurbiprofen axetil, Analgesia