Abstract: Objective The purpose of this study was to analyze the diagnostic performance of multi-slice spiral CT and enhanced liver acquisition with volume acceleration (LAVA) in the diagnosis of patients with intrahepatic space-occupying lesions (SOL). Methods 160 patients with intrahepatic SOL were encountered in our hospital between May 2020 and April 2023, and all underwent enhanced multi-slice spiral CT and LAVA scanning. The diagnostic efficacy of CT and LAVA scanning was analyzed based on the histo-pathological examination as the golden standard. Results Out of the 160 patients with intrahepatic SOL, the histo-pathological diagnosis included 87 malignant lesions (hepatocellular carcinoma in 79 cases and intrahepatic cholangiocarcinoma in 8 cases), and 73 benign lesions (cirrhotic nodules in 46 cases, nodular regenerative hyperplasia of liver in 20 cases and focal nodular hyperplasia in 7 cases; the CT diagnose malignant lesions in 77 cases and benign lesions in 83 cases, misdiagnosing 5 benign lesions into malignant and 15 malignant into benign ones, and the LAVA scan diagnose malignant in 86 cases and benign in 74 cases, misdiagnosing 3 benign lesions into malignant and 4 malignant into benign ones; the accuracy, sensitivity, specificity, positive predictive value and negative predictive value by CT scan were 87.5%, 82.8%, 93.2%, 93.5% and 81.9%, while they were 95.6%, 95.4%, 95.9%, 96.5% and 94.6%, respectively by LAVA scan, superior to those by CT diagnosis (P＜0.05). Conclusion The qualitative diagnostic performance by MR LAVA is superior, which might help the clinicians make an appropriate decisions to intervene early.

Key words: Hepatoma, Space-occupying lesions, CT, Enhanced liver acquisition with volume acceleration, Diagnosis