Abstract: Objective The aim of this study was to investigate the incidences of inflammatory bowel disease (IBD) and gallbladder polyp (GP) in patients with primary sclerosing cholangitis (PSC). Methods The clinical data of 201 patients with PSC in Eastern Branch of the First Hospital affiliated to Sun Yat-sen University between January 2000 and December 2018 were retrospectively analyzed. The diagnosis of PSC was based on endoscopic retrograde cholangiopancreatography (ERCP) and magnetic resonance cholangiopancreatography (MRCP), and the presence of GP and IBD were confirmed by abdominal CT , abdominal ultrasound or enteroscopy. Results A total of 23 patients (11.4%)with GP and 154(76.6%) with IBC were found out of this 201 cases with PSC; in 23 patients having GP, the incidences of IBD, ulcerative colitis (UC) and Crohn's disease (CD) were 87.0%, 73.9% and 8.7%, and in 178 patients without GP, they were 75.3%, 58.4% and 15.7%, not significant differences between the two groups (P>0.05); 15 patients with GP underwent cholecystectomy, and the histopathological examination post-operationally demonstrated that 5(33.3%) were adenocarcinoma, 3 (20.0%) were advanced atypical hyperplasia and another 7 belonged to benign polyp; the clinical data between patients with benign and malignant lesions were not significantly different (P>0.05). Conclusions GP and IBD are common lesions in patients with PSC, and the reason of these complications occurrence is not clear. The GP in patients with PSC, even a small polyp, has a risk of developing malignant tumors, which warrants early cholecystectomy as sooner as possible.

Key words: Primary sclerosing cholangitis, Gallbladder polyp, Inflammatory bowel disease, Transformation