Abstract: Objective The aim of this study was to explore the efficacy and safety of laparoscopic surgery in treatment of adult patients with congenital choledochal cyst (CCC). Methods The clinical data of 25 patients with CCC in our hospital between February 2012 and May 2018 were analyzed retrospectively. 17 patients received traditional open operation, and 8 received total laparoscopic surgery. Results The first feeding time, postoperative anal exhaust time, postoperative defecation time, hospital stay and intraoperative bleeding in patients with open surgery were (5.0±1.7) d, (3.8±1.5) d,(4.7±1.8) d, (9.4±2.3) d and (241.6±15.3)mL, significantly longer or greater than 【(3.0±1.1) d, (2.6±0.8) d, (3.1±1.3) d, (6.6±1.2) d and (94.0±9.7)mL, respectively, P<0.05】 in patients with laparoscopic surgery, while the operation time was (278.3±60.5)min, much longer than 【(231.7±41.2)min, P<0.05】 in patients with open surgery; 3 days after operation, serum C reactive protein level in patients with open surgery was (77.4±6.4)mg/L, significantly higher than 【(30.8±3.5)mg/L, P<0.05】 in patients with laparoscopic surgery; the total incidences of complications after operation were 37.5% and 58.8% in the two groups, no significant difference (P>0.05). Conclusion As compared with traditional open operation, the laparoscopic surgery is efficacious in dealing with patients with adult CCC, which might reduce the inflammatory response and intraoperative bleeding, and promote postoperative recovery.

Key words: Complex intrahepatic bile duct stone, Laparoscopic regular hepatectomy or lobectomy, Blood cortsisol, Peripheral blood T lymphocyte subsets