Abstract: Objective To summarize the characteristics of cholecystopathy in patients with primary biliary cholangitis（PBC）. Methods A total of 110 patients with PBC were enrolled in this study and their cholecystopathy was retrospectively analyzed. Results Out of 110 patients with PBC,83.6% had gallbladder wall roughness,42.7% had cholecystitis,40.0% had gallbladder wall thickening,22.7% had gallstone,19.1% had gallbladder polyp,and 18.2% had gallbladder wall edema;in 44 PBC patients with and 66 without gallbladder wall thickening,leukocyte counts were [（4.3±1.8）×10⁹/L vs. （5.2±2.3）×10⁹/L,P<0.05],hemoglobin was [（96.4±25.8） g/L vs. （122.1±18.2） g/L,P<0.05],platelet counts were [（122.3±101.7）×10⁹/L vs.（178.2±81.8）×10⁹/L,P<0.05],total serum bilirubin levels was [（71.1±81.1） μmol/L vs. （26.4±34.3） μmol/L,P<0.05],serum albumin level was [（31.2±6.1） g/L vs. （41.2±6.1） g/L,P<0.05],cholinesterase was [（3247.8±2058.9） U/L vs. （6829.3±2698.9） U/L,P<0.05],total cholesterol was [（3.6±1.4） mmol/L vs. （4.8±1.5） mmol/L,P<0.05],and inner diameters of portal vein were [（11.9±1.8） mm vs. （11.3±1.6）mm,P<0.05];the percentage of ascites in PBC patients without gall bladder wall thickening was 16.7%,significantly lower than 68.2% in PBC with gallbladder wall thickening（P<0.05）;the percentage of cholecystitis in the former group was 4.5%,significantly lower than 100.0% in the latter （P<0.05）;there was no patient with gallbladder wall edema in the former,while there was 45.5% with gallbladder wall edema in the latter（P<0.05）;the percentage of gallbladder wall roughness in the former was 100.0%,significantly higher than 59.1% （P<0.05） in the latter;in the former group,19.7% patients were with liver function Child class B or C,much lower than 68.2% in the latter （P<0.05）. Conclusion Cholecystopathy is a common manifestation in patients with PBC and gallbladder wall roughness,cholecystitis and gallbladder wall thickening are the most common types of cholecystopathy.

Key words: Primary biliary cholangitis, Cholecystopathy, Gallbladder wall thickening, Cholecystitis, Ultrasound