Abstract: Objective To observe the effect of paravertebral anaesthesia on the postoperative algesia and inflammatory response in patients after hepatobiliary surgery. Methods There were 70 patients who underwent hepatobiliary surgery in our hospital between April 2015 and April 2016，and they were randomly divided into study and control group with 35 cases in each. Patients in the control group received general anesthesia，while the patients in the study group were given paravertebral blockade at the base of general anesthesia. Visual analogue scales （VAS） were recorded，and serum tumor necrosis factor-α （TNF-α） and soluble triggering receptor expressed on myeloid cells-1（sTREM-1） were detected by ELISA. Result 3 h and 24 h after surgery，VAS scores in the study group were 3.3±1.6 and 2.9±0.9，much lower than those in the control group （4.3±1.9 and 3.7±1.3，respectively，P<0.05）；Serum TNF-α levels in the study group were （139.7±73.8） pg/ml and （137.6±79.2） pg/ml，significantly lower than those in the control group [（204.2±68.0） pg/ml and （231.5±77.6） pg/ml，P<0.01]； Serum levels of sTREM-1 in the study group were （221.3±79.9） pg/ml and （216.9±90.34） pg/ml，much lower than those in the control group [（279.8±125.6） pg/ml and （294.3±115.7） pg/ml，respectively，P<0.05]. Conclusion Paravertebral blockade at the base of general anesthesia may have a significantly analgesic effect and reduce the levels of serum inflammatory cytokines in patients after hepatobiliary surgery.

Key words: Hepatobiliary surgery, Paravertebral block, Visual analog scale, Tumor necrosis factor-alpha, Soluble triggering receptor expressed on myeloid cells-1