Abstract: Objective To investigate the effects of magnesium isoglycyrrhizinate combined with polyene phosphatidylcholine on serum cytokines in patients with chronic hepatitis B. Methods Eighty patients with chronic hepatitis B were admitted into our hospital between January 2015 and June 2016,and they were divided randomly into control and treatment group with forty cases in each group. Patients in control group were treated with polyene phosphatidylcholine,and those in treatment group were treated with magnesium isoglycyrrhizinate combined with polyene phosphatidylcholine. The regimen lasted for 4 weeks in both groups. The levels of serum cytokine were assayed by ELISA. Results At the end 4 weeks of treatment,serum tumor necrosis factor-α, interleukin-2 （IL-2）,L-4 and IL-10 in combination patients were （4.2±1.6） ng/L,（197.5±21.7） ng/L,（34.9±4.9） ng/L and （15.7±2.8） ng/L,respectively,obviously improved as compared with those in the control group [（6.3±2.2） ng/L,（164.1±18.6） ng/L,（53.6±6.6） ng/L,（28.6±4.2） ng/L,respectively,P<0.05 for all];serum alanine aminotransferase,total bilirubin,and international normalized ratio of prothrombin time in combination group were significantly lower than those in control group [（39.8±7.6） U/L vs. （76.6±11.3） U/L,（22.9±3.6） μmol/L vs. （30.5±3.9） μmol/L,and（1.2±0.1） vs.（1.4±0.2）,P<0.05 for all]. Conclusion Magnesium isoglycyrrhizinate combined with polyene phosphatidylcholine can improve clinical outcomes in patients with chronic hepatitis B,especially in decreasing serum levels of cytokines and liver function index.

Key words: Chronic hepatitis B, Magnesium isoglycyrrhizinate, Polyene phosphatidylcholine, Serum cytokines