急性药物性肝损伤患者肝病相关抗体阳性率调查及其临床意义

doi:10.3969/j.issn.1672-5069.2015.05.014

Abstract

Abstract: Objective To explore the prevalence of serial autoimmune antibody associated with liver diseases in patients with acute drug-induced liver injury（ADILI）. Methods A retrospective analysis was conducted over 104 patients with ADILI，admitted to the First Affiliated Hospital of Dalian Medical University from June 2002 to March 2012，and the prevalence of liver disease-related autoimmune antibody were analyzed. Results The positive rate of liver disease-related autoantibodies in 104 cases was 54.81%;Among the positive patients，ANA was positive in 47 cases （45.19%） and ASMA in 15 cases （14.42%）；The high ANA titer （≥1:320） accounted for 34.04% in ANA-positive cases；Two antibodies positive accounted for 26.32% in 57 antibody-positive cases，and ANA/ASMA was the most common；Serum ANA/AMA/AMA-M2 positive accounted for 8.77% in 57 antibody-positive cases；Female had higher antibody positive rate than male did，and the antibody positive rate was higher in patients with hepatocellular injury pattern than those in cholestatic or mixed pattern. Conclusions The prevalence of liver disease-related antibodies was positive in more than half the patients with ADILI，especially common in females and cases of hepatocellular injury pattern. Clinician should keep an open eye on differential diagnosis.

Key words: Drug-induced liver injury, Liver disease-related antibodies, Prevalence

Lu Dan，Duan Zhijun. Prevalence of liver disease-related antibodies in patients with acute drug-induced liver injury and its clinical significance[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2015, 18(5): 504-507.

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Prevalence of liver disease-related antibodies in patients with acute drug-induced liver injury and its clinical significance

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