Abstract: Objective To investigate the common agents related to drug-induced liver injury（DILI） in our hospitalized patients and to observe the clinical efficacy of ursodeoxycholic acid in treatment of patients with DILI. Methods Two hundred patients with DILI were recruited in this study and the common agents were analyzed. The patients were divided into two groups. Patients in control group received magnesium isoglycyrrhizinate, glutathione and polyene phosphatidylcholine（one,two,and all or any combination of them） for four weeks. Ademetionine was given when hyperbilirubinemia appeared. The patients in observation group received additionally ursodeoxycholic acid for four weeks at the base treatment in the control. Results The leading agents in our patients with DILI were immunosuppressive agents（34.0%）,followed by traditional Chinese medicin（28.5%）,and other common agents were antibacterial（13.0%）,antitubercular agents（7.5%）, chemotherapeutics（7.5%）,and antipyretic analgesics（4.5%）. Liver function improved in both groups after four week treatment,while the efficacy was superior in ursodeoxycholic acid-treated patients（P<0.01）. Conclusion Immunosuppressive agents are the main causes of DILI in our hospitalized patients, and the ursodeoxycholic acid could improve the efficacy of basic treatment such as glycyrrhizin in patients with DILI.

Key words: Drug-induced liver injury, Common agents, Ursodeoxycholic acid, Traditional Chinese medicine