慢性乙型肝炎患者认知功能的调查研究

doi:10.3969/j.issn.1672-5069.2012.04.014

Abstract

Abstract: Objective To measure the cognitive functions in patients with chronic hepatitis B （CHB）. Method Number connection test,digit symbol test,Stroop color-word test and clock drawing test were conducted in 196 patients with CHB and in 196 healthy controls. Results The score of clock drawing test in patients with CHB（22.8±4.9）was lower than that in healthy controls（23.9±4.0,t=-2.44,P<0.05）;While the results of other tests in the two groups were similar（P>0.05）. Conclusion CHB patients have executive dysfunction,but they do not show impairment in attention.

Key words: Chronic hepatitis B, Cognitive function, Number connection test

Su Li, Sun Yumei, Lin Keke, et al.. Investigation of cognitive functions in patients with chronic hepatitis B[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2012, 15(4): 312-314.

References

[1] Dhiman RK,Saraswat VA,Sharma BK,et al. Minimal hepatic encephalopathy:Consensus statement of a working party of the Indian National Association for Study of the Liver. J Gastroenterol Hepatol,2010,25:1029-1041.
[2] Ortiz M,Jacas C,Cordoba J. Minimal hepatic encephalopathy: diagnosis,clinical significance and recommendations. J Hepatol, 2005,42（Suppl）:S45-S53.
[3] Sorrell JH,Zolnikov BJ,Sharma A. Cognitive impairment in people diagnosed with end-stage liver disease evaluated for liver transplantation. Psychiat Clin Neurosci,2006,60（2）:174-181.
[4] Bajaj JS,Hafeezullah M,Franco J. Inhibitory control test for the diagnosis of minimal hepatic encephalopathy. Gastroenterology,2008,135:1591-1600.
[5] 曾峥,李瑜元,聂玉强. 亚临床肝性脑病的流行病学调查. 中华肝脏病杂志,2003,11（11）:680-682.
[6] Perry W,Hilsabeck RC,Hassanein TI. Cognitive dysfunction in chronic hepatitis C:A review. Dig Dis Sci,2008,53（2）:307-321.
[7] Hilsabeck RC,Perry W,Hassanein TI. Neuropsychological impairment in patients with chronic hepatitis C. Hepatology,2002,35（2）:440-446.
[8] Hilsabeck RC,Hassanein TI,Carlson MD,et al. Cognitive functioning and psychiatric symptomatology in patients with chronic hepatitis C. J Int Neuropsycho Society,2003,9（6）:847.
[9] Quarantini LC,Miranda-Scippa A,Batista-Neves S,et al. A neuropsychological study comparing patients infected with HCV and HBV without psychiatric comorbidities. J Med Virol,2009,81（7）:1184-1188.
[10] 陆骏超,郭起浩,洪霞,等. 连线测验（中文修订版）在早期识别阿尔茨海默病中的作用. 中国临床心理学杂志,2006,14（2）:118-120.
[11] 龚耀先. 中国修订韦氏成人智力量表手册. 湖南地图出版社, 1992:35.
[12] 郭起浩,洪霞,吕传真,等. Stroop色词测验在早期识别阿尔茨海默病中的作用. 中华神经医学杂志,2005,4（7）:701-704.
[13] 陈燕,吴勤花. Stroop色词测验在不同严重度的阿尔茨海默病中的表现. 精神疾病与精神卫生,2006,6（2）:131-132.
[14] 曾峥,李瑜元,贾林,等. 慢性肝炎患者的亚临床肝性脑病患病状况分析. 中国医药,2006,1（5）:281-283.
[15] 保志军,邱德凯,马雄,等. 简易智能测试在诊断轻微肝性脑病中的初步应用. 中华消化杂志,2006,26（9）:606-609.
[16] Amodio P,Schiff S,Piccolo FD,et al. Attention dysfunction in cirrhotic patients:An inquiry on the role of executive control, Attention orienting and focusing. Metabol Brain Dis,2005,20（2）:115.
[17] 赵杰. 影响二语习惯的非语言因素：注意力. 中国成人教育, 2010,12（5）:110-111.
[18] Katerina K,Konstantinos A,Konstantinos T. Neuropsychological function in Greek patients with chronic hepatitis C. Liver Int, 2007,27（6）:798-805.
[19] 聂玉强,李瑜元,沙卫红,等. 智力测验调查亚临床肝性脑病的发病. 中华消化杂志,2001,21（11）:677-679.
[20] 杜耀民,赵擎宇,黄东锋. 肝硬化患者的认知功能表现. 中国临床康复,2004,8（27）:5802-5803.
[21] Hill EL. Evaluating the theory of executive dysfunction in autism. Development Rev,2004,24（2）:189-233.
[22] Farag NH,Rashed H,Hassan M,et al. Hepatitis C infection, cognition,and inflammation in an Egyptian sample. J Med Virol,2011,83（2）:261-266.
[23] 廖玲敏,马树华,王兆新,等. PET和fMRI对肝性脑病的研究进展. 中国医学影像技术,2010,26（7）:1370-1372.
[24] 倪媛媛,李红. 从生理机制探讨心理理论与执行功能的关系. 西南师范大学学报（自然科学版）,2010,35（5）:75-79.
[25] 商庆华,徐传镇,卓海龙,等. 脑组织乙型肝炎病毒感染与病毒载量的关系. 中华传染病杂志,2004,22（1）:55-57.
[26] 彭丹. 慢性HCV感染患者认知功能研究及其机制初步探讨. 重庆:重庆医科大学出版社,2009：123.

Investigation of cognitive functions in patients with chronic hepatitis B

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