Abstract: Objective To investigate the correlations of serum HBV DNA and HBsAg and HBeAg levels in patients with chronic hepatitis B. Methods 951 patients with CHB were enrolled. Serum HBV DNA was tested by fluorescence quantitative polymerase chain reaction,and HBsAg and HBeAg were detected by chemiluminesent microparticle immunoassay. Results 53.6% patients were HBV DNA positive in 951 patients with CHB; The serum HBsAg and HBeAg concentrations were positively correlated with serum HBV DNA levels（rs=0.45 and re=0.49, respectively,P<0.05）;The serum HBV DNA were divided into 3 groups（eg.<3 lgcopies/ml,3 to 7 lgcopies/ml and ≥7 lgcopies/ml）.There was an significant differences in serum HBsAg and HBeAg levels among the 3 groups （P<0.05）;There was also an significant differences in serum HBV DNA levels among different serum HBsAg levels（eg. <1000 IU/ml,1000~10000 IU/ml and ≥10000 IU/ml,P<0.05）. Conclusion Serum HBsAg concentration is related to serum HBV DNA levels in patients with hepatitis B,but it is not feasible in most cases to use HBsAg concentration for monitoring their serum HBV levels .

Key words: Chronic hepatitis B, Hepatitis B surface antigens, Hepatitis B e antigens, HBV DNA