Abstract: Objective To explore the value of contrast-enhanced ultrasonography in diagnosis of liver fibrosis in patients with chronic hepatitis B. Method 80 patients with chronic hepatitis B and 10 healthy persons were recruited in this study. The ultrasound contrast agent,SonoVue,was injected through cubital vein,then the hepatic artery arrival time（HAAT）,portal vein arrival time（PVAT） and hepatic vein arrival time（HVAT） were recorded,and the interval time between hepatic artery arrival time and hepatic vein arrival time（HAVTT） was calculated. Result HVAT and HAVTT shorten in hepatic fibirosis S₃ and S₄（P<0.05）;the areas under ROC curve of HVAT and HAVTT were 0.87 and 0.89,respectively,for the diagnosis of hepatic fibrosis S₄（P<0.01）;When HVAT≤21s as the cut-off value for diagnosis of hepatic fibrosis S₄,the sensitivity was 88%,the specificity was 95%;when HAVTT≤10s as the cut-off value for diagnosis of hepatic fibrosis S₄,the sensitivity was 90%,the specificity was 97%. Conclusion Contrast-enhanced ultrasonography has some value in diagnosis of obvious hepatic fibrosis,but it might skip over some mild hepatic fibrosis in patients with chronic hepatitis B.

Key words: Hepatitis B, Liver fibrosis, Contrast-enhanced ultrasonography, Diagnosis