ω-3多不饱和脂肪酸防治非酒精性脂肪性肝炎大鼠的初步观察*

doi:10.3969/j.issn.1672-5069.2011.01.005

JOURNAL OF PRACTICAL HEPATOLOGY ›› 2011, Vol. 14 ›› Issue (1): 15-17.doi: 10.3969/j.issn.1672-5069.2011.01.005

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The efficacy of ω-3 unsaturated fatty acid on NASH rats

DING Wenjin，DUAN Xiaoyan，FAN Jiangao

Department of Gastroenterology，Xinhua Hospital，Affiliated to Shanghai Jiaotong University，Shanghai 200092，China

Received:2010-10-29 Online:2011-02-10 Published:2016-04-15

Abstract

Abstract: Objective To observe the efficacy of ω-3 unsaturated fatty acid on lipid and glycometabolism， as well as on adipocytokines in rats with NASH. Methods 32 rats were divided into 3 groups（control/NASH/therapy group）. Control group was fed with normal diet，and the other two with high-fat diet. ω-3 unsaturated fatty acid was added to therapy group from 8 weeks to 12 weeks. The weight，FBS，ALT，AST，TC，TG and adipocytokines were measured. Results NASH model was established successfully. The weight，TC，TG and ALT decreased in therapy group，as compared with those in rats with NASH；Therapy group showed lower leptin，resistin and higher adiponectin levels than in NASH group. Conclusion Unsaturated fatty acid may improve lipid and glycometabolism on NASH rats，and it can also regulate the expression of adipocytokines.

Key words: NASH, Unsaturated fatty acid, Adipocytokines

DING Wenjin，DUAN Xiaoyan，FAN Jiangao. The efficacy of ω-3 unsaturated fatty acid on NASH rats[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2011, 14(1): 15-17.

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The efficacy of ω-3 unsaturated fatty acid on NASH rats

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