HBV基因多位点变异与肝衰竭的关系

摘要/Abstract

摘要： 乙型肝炎病毒感染可引起人类急慢性肝炎、肝硬化、肝功能衰竭和肝细胞癌等。分子病毒学研究发现HBV基因组四个开放读码框基因均可发生变异,其中一些变异可能与肝衰竭的发生有密切关系。本文阐述近年有关HBV基因组变异与临床发生肝功能衰竭的关系。

张骏飞，综述, 陈从新，审校. HBV基因多位点变异与肝衰竭的关系[J]. 实用肝脏病杂志, 2009, 12(6): 473-476.

[1] 中华医学会感染病学分会肝衰竭与人工肝学组和肝病学分会重型肝病与人工肝学组. 肝衰竭诊疗指南[J]. 实用肝脏病杂志,2006,9：321-324.
[2] HOU JL,LIN Y,WATERS J,et al. Detection and significance of a G1867T variant of hepatitis B virus in Chinese patiens with fulminant hepatitis[J]. J Gen Virol,2002,83（6）;2291-2298.
[3] TILLMANN HL. Antiviral therapy and resistance with hepatitis B virus infection[J]. World J Gastroenterol,2007,13（1）：125-140.
[4] HUY TT,ABE K,et al. Molecular epidemiology of hepatitis B and C virus infections in Asia[J]. Pediatr Int,2004,46（2）：223-301.
[5] HUNT CM,MCGILL JM,ALLEN MI,et al. Clinical relevance of heaptitis B viral mutations[J]. Hepatology,2000,31（5）：1037-1044.
[6] HUY TT,USHIJIMA H,WIN KM,et al. High prevalence of hepatitis B virus pre-s mutant in countries where it is endemic and its relationship with genotype and chronicity[J]. J Clin Mirobiol,2003,41（12）：5449-5455.
[7] FAN YF,LU CC,CHEN WC,et al. Prevalence and significance of hepatitis B virus （HBV） pre-s mutants in serum and liver at different replcative stages of chronic HBV infection[J]. Hepatology,2001,33（1）：277-286.
[8] CHEN CH,HUNG CH,LEE CM,et al. Pre-s deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg- negative patients[J]. Gastroenterology,2007,133（5）：1466-1474.
[9] ENGELKE M,MILLS K,SEITZ S,et al. Characterization of a hepatitis B and hepatitis delta virus receptor binding site[J]. Hepatology,2006,43（4）：750-760.
[10] POLLICINO T,ZANETTI AR,CACCIOLA I,et al. Pre-S2 defective hepatitis B virus infection in patients with fulminant hepatitis[J]. Hepatology,1997,26（2）：495-499.
[11] KALININA T,RIU A,FISCHER L,et al. A dominant hepatitis B virus population defective in virus secretion because of several S-gene mutations from a patient with fulminant hepatitis[J]. Hepatology,2001,34（20）：385-394.
[12] WU W,CHEN Y,RUAN B,et al. Gene heterogeneigy of hepatitis B virus isolates from patients with severe hepatitis B[J]. Hepatobiliary Pancreat Dis Int,2005,4（4）：530-534.
[13] BAUMERT TF,BARTH H,BLUM HE,et al. Genetic variants of hepatitis B virus and their clinical relevance[J].Minerva Gastroenterol Dietol,2005,51（1）：95-108.
[14] YARKIN F,ALTUN Z. The prevalence of hepatitis B virus precore mutant in patients with chronic hepatitis B virus infection[J]. Clin Microbiol Infect,2004,5：1-4.
[15] SHIRAKI K,HAMADA M,SUGIMOTO K,et al. Detection of precore mutant hepatitis B virus genome in patients with acute and fulminant hepatitis using mutation site-specific assay（MSSA）[J]. Hepatogastroenterology,2002,49（47）：1352-1356.
[16] 郭亚兵,侯金林,骆抗先,等. 重型乙型肝炎e抗原阴性患者前C变异株及其体外翻译[J]. 中华肝脏病杂志,2001,9（1）：42-44.
[17] KOBAYASHI M,ARASE Y,IKEDA K,et al. Precore wild-type hepatitis B virus with G1896 in the resolution of persistent hepatitis B virus infection[J]. Intervirology,2003,46（3）：157-163.
[18] DAI MS,LU JJ,CHEN YC,et al. Reactivation of precore mutant hepatitis B virus in chemotherapy-treated patients[J]. Cancer,2001,92（11）：2927-2932.
[19] LI KS,YAMASHIRO T,SUNMIE A,et al. Hepatitis B virus harboring nucleotide deletions in the core promoter region and genotype B carriers[J]. J Clin Virol,2001,23（1-2）：97-106.
[20] SAINOKAMI S,ABE K,SATO A,et al. Initial load of hepatitis B virus（HBV）,its changing profile,and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection[J]. J Gastroenterol,2007,42（3）:241-249.
[21] OKAMOTO H,TS UDA F AHANEY AK,et al. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen[J]. J Virol,1994,68（12）：8102-8110.
[22] KUSUMOTO K,YATSUHASHI H,NAKAO R,et al.Detection of HBV core promoter and precore mutations helps distinguish flares of chronic hepatitis from acute hepatitis B[J]. J Gastroenterol Hepatol,2008,23（5）：790-793.
[23] OZASA A,TANAKA Y,ORITO E,et al. Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection[J]. Hepatology,2006,44（2）：326-334.
[24] JAMMEH S,TAVNER F,WATSON R,et al. Effect of basal core promoter and pre-core mutations on hepatitis B virus replication[J]. J Gen Virol,2008,89（4）:901-909.
[25] TONG S,KIM KH,CHANTE C,et al. Hepatitis B virus e antigen variants [J]. Int J Med Sci,2005,2（1）：2-7.
[26] BAUMERT TF,YANG C,SCHURMANN P,et al. Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis in primary Tupaia hepatocytes[J]. Hepatology,2005,41（2）：247-256.
[27] HAYASHI K,KATANO Y,CHUONG TX,et al. Prevalence of hepatitis B virus subgenotypes and basal core promoter,precroe variants in patiens with acute hepatitis B in central Vietnam[J]. Intervirology,2009,52（1）：22-28.
[28] FRIEDT M,GERNER P,WINTERMEYER P,et al. Complete hepatitis B virus genome analysis in HBsAg positive mothers and their infants with fulminant hepatitis B[J].BMC Gastroenterol,2004,4（1）：11.
[39] GEROLAMI R,HENRY M,BORENTAIN P,et al. Fulminant hepatitis B associated with a specific insertion in the basal core promoter region of hepatitis B virus DNA after immunosuppressive treatment[J]. Clin Infect Dis,2005,40（4）：24-27.
[30] CHEN Y,MICHITAKA K,MATSUBARA H,et al. Complete genome sequence of hepatitis B virus （HBV） from a patient with fulminant hepatitis without precore and core promoter mutations：comparison with HBV from a patient with acute hepatitis infected from the same infectious source[J]. J Hepatol,2003,38（1）：84-90.
[31] LEIFELD L,NATTERMANN J,FIELENBACH M,et al. Intrahepatic activation of caspases in human fulminant hepatic failure[J]. Liver Int,2006, 26（7）：872-879.
[32] MITA A,HASHIKURA Y,TAGAWA Y,et al. Expression of Fas ligand by hepatic macrophages in patients with fulminant hepatic failure[J]. Am J Gastroenterol,2005,100（11）：2551- 2559.
[33] HOU W,LIU KZ,LI MW,et al. Effect of IFN alpha-2a on Fas expression and apoptosis rate of peripheral blood cytotoxic T cells in patients with hepatitis B[J]. Hepatobiliary Pancreat Dis Int,2005,4（3）：403- 405.
[34] GANDHE SS,CHADHA MS,WALIMBE AM,et al. Hepatitis B virus：prevalence of precore/core promoter mutants in different clinical categories of Indian patients[J]. J Viral Hepat,2003,10（5）：367-382.
[35] LIU CJ,KAO JH,LAI MY,et al. Precore/core promoter mutations and genotypes of hepatitis B virus in chronic hepatitis B patients with fulminant or subfulminant hepatitis[J]. J Med Virol,2004,72（4）：545-550.
[36] LI W,IKEMASTU H,YAMAJI TK,et al. Hepatitis B virus genomes of chronic heptatitis patients do not contain specific mutations related to acute exacerbation[J]. Dig Dis Sci,2001,46：2104-2112.
[37] KOMASTU H,INUI A,MORINISHI Y,et al. Sequence analysis of hepatitis B virus genomes from an infant with acute severe hepatits and a hepatitis B e antigen-positive carrier mother[J]. J Med Virol,2001,65:457-462.
[38] MAYERAT C,MANTEGANI A,SPERTINI F,et al. Mutations in the basal core promoter and percore/core gene of hepatitis B virus in patients with chronic active but not acute hepatitis B[J]. Eur J Clin Microbiol Infect Dis,1999,18（12）：871-878.
[39] SUGIYAMA M,TANAKA Y,KURBANOV F,et al. Influences on hepatitis B virus replication by a naturally occurring mutation in the core gene[J]. Virology,2007,365（2）：285-291.
[40] KARAYIANNIS P,ALEXOPOULOU A,HADZIYANNIS S,et al. Fulminant hepatitis associated with hepatitis B virus e antigen-negative infection：importance of hosfactors[J].Hepatology,1995,22（6）：1628-1628.
[41] HENKLER F,HOARE J,WASEEM N,et a1. Intracellular localization of the hepatitis B virus HBx protein[J]. J Gen Virol,2001,82：871-882.
[42] KANEKO M,UCHIDA T,MORIYAMA M,et al. Probable implication of mutations of the X open reading frame in the onset of fulminant hepatitis B[J]. Med Virol,1995,47（3）：204-208.
[43] ARBUTHNOT P,CAPOVILLA A,KEW M. Putative role of hepatitis B virus X protein in hepatocarcinogenesis：effects on apoptosis,DNA repair,mitogen-activated protein kinase and JAK/STAT pathways[J]. J Gastroenterol Hepatol,2000,15（4）：357-368.
[44] INOUE K,OGAWA O,YAMADA M,et al. Possible association of vigorous hepatitis B virus replication with the development of fulminant hepatitis[J]. J Gastroenterol,2006,41（4）：383-387.
[45] LIAW YF. Management of YMDD mutations during lamivudine therapy in patients with chronic hepatitis B[J]. J Gastroenterol Hepatol,2002,17（Suppl3）：S333-S337.

HBV基因多位点变异与肝衰竭的关系

Differential proteomic analysis of liver plasma membrane in hepatic fibrosis rats treated with Fufang Biejia

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	吴海义, 陈建新. 四种诊断模型诊断乙型肝炎病毒携带者肝纤维化的效能分析^*[J]. 实用肝脏病杂志, 2019, 22(6): 832-835.
[2]	朱玉成, 闫家微, 孙景坤, 张秋月. 慢加急性肝衰竭患者血清二胺氧化酶水平及其临床意义探讨*[J]. 实用肝脏病杂志, 2019, 22(5): 672-675.
[3]	宋海燕, 陈曦, 张骏飞, 方雪晴, 董静, 陈照林, 潘劲劲, 刘波, 陈从新. 伏立康唑治疗肝衰竭并发肺部真菌感染患者疗效初步研究[J]. 实用肝脏病杂志, 2019, 22(5): 676-679.
[4]	张璇, 唐小云, 唐春银, 石学魁, 王惠琦, 张晓东, 沈海萍, 杨春辉. 中药方剂赤白汤对D-氨基半乳糖诱导的急性肝衰竭小鼠肠道菌群的影响研究^*[J]. 实用肝脏病杂志, 2019, 22(4): 478-481.
[5]	王媛, 党盼玉, 王伟. 血浆置换联合连续性血浆透析滤过治疗慢加急性肝衰竭患者临床疗效及其对血浆细胞因子水平的影响[J]. 实用肝脏病杂志, 2019, 22(4): 541-544.
[6]	彭思璐, 刘冰, 孙宏, 林剑, 潘志颖, 邓存良. HBV相关慢加急性肝衰竭患者预后及其影响因素分析^*[J]. 实用肝脏病杂志, 2019, 22(4): 545-548.
[7]	钟宋, 刘玉元, 刘树人, 周国柱, 刘崇文, 欧阳石. 慢性乙型肝炎患者肝组织自然杀伤细胞G2D表达水平的变化及其临床意义[J]. 实用肝脏病杂志, 2019, 22(3): 341-344.
[8]	潘劲劲, 董静, 宋海燕, 张俊飞, 陈照林, 刘波. 应用糖皮质激素治疗核苷（酸）类似物撤药性肝炎患者临床疗效评价[J]. 实用肝脏病杂志, 2019, 22(3): 357-360.
[9]	周积云,马勇,丁体龙,涂远航,陈策. 慢性乙型肝炎患者外周血CD8⁺CD28⁺T淋巴细胞百分比的变化及其临床意义探讨[J]. 实用肝脏病杂志, 2019, 22(2): 180-183.
[10]	宋芳娇,朱冰,吕飒,田华,王海波,辛绍杰,游绍莉. 314例药物性肝衰竭患者临床特征分析^*[J]. 实用肝脏病杂志, 2019, 22(2): 216-219.
[11]	高朋彬,赵晓彦,秦浩,吴凤影,钟海振,王琳,贾慧娜,李树娟. 戊型肝炎肝衰竭死亡原因分析^*[J]. 实用肝脏病杂志, 2019, 22(2): 220-223.
[12]	张秀灵,段志文,杨瑞东,张晓敏,杨莉,杨海秋,李武. 血源紧张条件下血浆置换联合双重血浆分子吸附系统治疗早中期肝衰竭患者临床研究^*[J]. 实用肝脏病杂志, 2019, 22(2): 289-290.
[13]	范建高. 2018年《实用肝脏病杂志》精彩回顾[J]. 实用肝脏病杂志, 2019, 22(1): 1-3.
[14]	谭静, 叶晓林, 王慧. 妊娠中晚期应用替比夫定阻断HBsAg阳性孕妇HBV母婴传播效果及对婴儿接种乙肝疫苗应答的影响^*[J]. 实用肝脏病杂志, 2019, 22(1): 49-52.
[15]	陈海鸥, 刘适. 慢加急性乙型肝炎肝衰竭患者血清IL-10和GP73水平检测及其临床意义[J]. 实用肝脏病杂志, 2019, 22(1): 73-76.