非酒精性脂肪性肝炎患者心脏舒张功能变化及其与肝功能的相关性研究

doi:10.3969/j.issn.1672-5069.2010.06.012

实用肝脏病杂志 ›› 2010, Vol. 13 ›› Issue (6): 433-435.doi: 10.3969/j.issn.1672-5069.2010.06.012

非酒精性脂肪性肝炎患者心脏舒张功能变化及其与肝功能的相关性研究

黄健,黄群,陈小珠,周锋,陈小华,何剑琴

518033 广东省深圳市广东医学院附属福田人民医院消化内科（黄健，黄群，周锋，陈小华，何剑琴）；
超声科（陈小珠）

收稿日期:2010-09-09 出版日期:2010-12-10 发布日期:2016-04-18
作者简介:黄健女，32岁，硕士研究生，主治医师。主要从事脂肪肝的防治研究。E-mail:wangkin89@hotmail.com

Relationship between cardiac diastolic function and live function in patients with nonalcoholic steatosis hepatitis

HUANG Jian，HUANG Qun，CHEN Xiaozhu，et al.

Department of Gastroenterology，Futian People’s Hospital，Affilicated to Guangdong Medical College，Shenzhen 518033，China

Received:2010-09-09 Online:2010-12-10 Published:2016-04-18

摘要/Abstract

摘要： 目的了解NASH患者心脏舒张功能。方法采用彩色多普勒超声心动图检查64例单纯性脂肪肝（SFL）、56例脂肪性肝炎（NASH）患者和120例正常对照者。应用E/A比值评价心脏的舒张功能。结果 NASH组心脏舒张功能不全（DCD）的发生率为44.6%，显著高于SFL组的10.9%及正常对照组的5.0%（P<0.01）；正常对照组、SFL组及NASH组E/A比值分别为1.3±0.2、1.3±0.2和1.0±0.3（P<0.01）；NASH组ALT、AST和GGT水平比SFL组及正常对照组显著升高（P<0.01）。结论 NASH患者常伴有DCD和血清GGT显著升高。

关键词: 非酒精性脂肪性肝病, 非酒精性脂肪性肝炎, 心脏舒张功能不全, 彩色多普勒超声, 肝功能

Abstract: Objective To explore the relationship between cardiac diastolic function and liver function in patients with nonalcoholic steatosis hepatitis（NASH）. Methods 64 patients with simple fatty liver（SFL），56 patients with NASH and 120 matched healthy controls were examined by color Doppler echocardiography in this study. Diastolic cardiac dysfunction（DCD）was defined when the patient had an E/A ratio less than 1. Results The incidence of diastolic cardiac dysfunction in patients with NASH was significantly higher than that in patients with SFL and normal controls（44.6% vs. 10.9% and 5.0%，P<0.01）；NASH patients had an lower E/A ratio than normal controls and SFL patients（1.0±0.3 vs. 1.3±0.20 and 1.3±0.20，P<0.01）；and the patients with NASH had a significantly higher level of serum ALT，AST and GGT than in patients with SFL.Conclusion DCD is commonly seen in patients with NASH.

Key words: Nonalcoholic fatty liver disease, Nonalcoholic steatosis hepatitis, Cardiac diastolic dysfunction, Color doppler echocardiography, Live function

黄健,黄群,陈小珠,周锋,陈小华,何剑琴. 非酒精性脂肪性肝炎患者心脏舒张功能变化及其与肝功能的相关性研究[J]. 实用肝脏病杂志, 2010, 13(6): 433-435.

HUANG Jian，HUANG Qun，CHEN Xiaozhu，et al.. Relationship between cardiac diastolic function and live function in patients with nonalcoholic steatosis hepatitis[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2010, 13(6): 433-435.

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非酒精性脂肪性肝炎患者心脏舒张功能变化及其与肝功能的相关性研究

Relationship between cardiac diastolic function and live function in patients with nonalcoholic steatosis hepatitis

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