肝细胞癌患者血清ECM1、MMP-9和VEGF水平的变化及其意义*

doi:10.3969/j.issn.1672-5069.2010.06.009

实用肝脏病杂志 ›› 2010, Vol. 13 ›› Issue (6): 424-427.doi: 10.3969/j.issn.1672-5069.2010.06.009

肝细胞癌患者血清ECM1、MMP-9和VEGF水平的变化及其意义*

陈浩,李建生,荚卫东,王伟,许戈良,马金良

230001 合肥市安徽医科大学附属省立医院肝脏外科

收稿日期:2010-08-23 出版日期:2010-12-10 发布日期:2016-04-18
通讯作者: 李建生，E-mail:lijiansheng1953@163.com
作者简介:陈浩男，25岁，硕士研究生。主要从事原发性肝癌转移复发的基础和临床研究
基金资助:
国家自然科学基金项目（30772097）；安徽省高等学校省级自然科学研究项目（KJ2010B386）；安徽省自然科学基金项目（070413073）；安徽省优秀青年科技基金项目（08040106818）；安徽省“115”产业创新团队项目

Serum levels of extracellular matrix protein 1，MMP-9 and VEGF in patients with hepatocellular carcinoma

CHEN Hao，LI Jiansheng，JIA Weidong，et al.

Department of Hepatic Surgery，Affiliated Provincial Hospital，Anhui Medical University，Hefei 230001，China

Received:2010-08-23 Online:2010-12-10 Published:2016-04-18

摘要/Abstract

摘要： 目的检测肝细胞癌患者血清ECM1水平，分析其与MMP-9和VEGF水平间的关系。方法应用酶联免疫吸附法测定40例肝癌患者血清ECM1、MMP-9和VEGF水平，分析其与肿瘤临床与病理特征间的关系。结果 40例肝癌患者血清ECM1、MMP-9和VEGF平均水平分别为150.01±5.85pg/ml、467±30.81μg/l和751.29±51.08pg/ml；三者水平均与肿瘤包膜、TNM分级、发生淋巴结转移和肿瘤分期有关（P<0.005），而ECM1和VEGF还与血管侵犯有关（P<0.005）；ECM1与MMP-9和VEGF水平呈显著正相关（r=0.438，P=0.005；r=0.427，P=0.006）。结论 ECM1可能通过与MMP-9和VEGF相互作用而促进了肝癌血管生成和侵袭转移。

关键词: 肝细胞癌, 细胞外基质蛋白-1, 血管内皮生长因子, 基质金属蛋白酶-9

Abstract: Objective To investigate the serum levels of extracellular matrix protein 1（ECM1），matrix metalloproteinase-9（MMP-9）and vascular endothelial growth factor（VEGF）in patients with HCC. Methods Serum levels of ECM1，MMP-9 and VEGF were detected by enzyme-linked immunosorbent assay in 40 patients with HCC. Results The serum ECM1，MMP-9 and VEGF levels were 150.01±5.85pg/ml，467±30.81μg/l and 751.29±51.08pg/ml；The serum levels of them were significantly associated with tumor capsula，TNM stage，lymph metastasis and Edmondson grade；ECM1 levels was positively correlated with MMP-9 and VEGF levels（r=0.438，P=0.005；r=0.427，P=0.006）.Conclusion ECM1 may stimulate angiogenesis，metastasis and invasion of HCC via interaction with MMP-9 and VEGF.

Key words: Hepatoma, Extracellular matrix protein 1, Vascular endothelial growth factor, Matrix metalloproteinase-9

陈浩,李建生,荚卫东,王伟,许戈良,马金良. 肝细胞癌患者血清ECM1、MMP-9和VEGF水平的变化及其意义*[J]. 实用肝脏病杂志, 2010, 13(6): 424-427.

CHEN Hao，LI Jiansheng，JIA Weidong，et al.. Serum levels of extracellular matrix protein 1，MMP-9 and VEGF in patients with hepatocellular carcinoma[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2010, 13(6): 424-427.

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肝细胞癌患者血清ECM1、MMP-9和VEGF水平的变化及其意义*

Serum levels of extracellular matrix protein 1，MMP-9 and VEGF in patients with hepatocellular carcinoma

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