miRNAs与肝细胞癌发生研究进展

doi:10.3969/j.issn.1672-5069.2014.02.031

摘要/Abstract

摘要： MicroRNAs（miRNAs）是一类长度为 21～25个核苷酸的非编码小分子RNA,参与基因转录后调控。研究发现，miRNAs的异常表达与疾病，尤其是恶性肿瘤的发生发展密切相关。miRNAs在不同癌症中水平不同。研究证明，miRNAs可以作为肝细胞癌分类、预后和早期诊断的生物学标志，并有望成为体内治疗的新靶点。本文对各类miRNAs小分子与肝细胞癌发生的关系，及其在临床上的应用潜能等进行了介绍。

关键词: 肝细胞癌, MicroRNAs, 诊断, 治疗

Abstract: MicroRNAs（miRNAs） are a class of 21 to 25 nucleotides non-coding small RNAs that regulate post-transcriptionally gene expression. Recent findings show that the abnormal expression of miRNAs is closely related to a number of diseases，especially the development of malignant tumor. miRNAs are expressed at different levels in various cancers.Studies shows that miRNAs can be used as biological markers for histological classification，prognosis and early diagnosis of hepatocellular carcinoma，and are expected to become a new therapeutic target in vivo. In this paper，a number of known small miRNAs are reviewed for their effect in carcinogenesis in liver cancer.

Key words: Hepatocellular carcinoma, MicroRNAs, Diagnosis, Treatment

裴丽玲综述，李建生，任维华审校. miRNAs与肝细胞癌发生研究进展[J]. 实用肝脏病杂志, 2014, 17(2): 221-224.

Pei Liling，Li Jiansheng，Ren Weihua.. Progress in microRNAs in the development of hepatocellular carcinoma[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2014, 17(2): 221-224.

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