关键词: 自身免疫性肝病, 临床特征, 肝活检, 治疗

Abstract: Objective To study the clinical characteristics of hospitalized patients with autoimmune liver diseases （AILD）. Methods The clinical data including age and gender,laboratory tests,liver biopsy results and treatment plans in 102 hospitalized patients with AILD were collected and analyzed. Results The mean age of 102 patients was（50.32±12.87） years old and the female/male ratio was 5.8/1. The mean age of 51 hospitalized patients with autoimmune hepatitis（AIH） was（48.38±13.88）years old and the female/male ratio was 9.4/1;the mean age of 25 hospitalized patients with primary biliary cirrhosis（PBC） was（54.95±14.33） years old and the female/male ratio was 4/1. The differences in average age and gender ratio between the AIH and PBC patients were not statistically significant;Among the newly diagnosed patients who had underwent liver biopsies,the mean level of serum alanine aminotransferase（ALT） in 22 patients with AIH was （565.3 ± 482.9） U/L,significantly higher than in 5 patients with PBC [（75.5±25.0） U/L,P<0.05）];the mean level of serum IgM in patients with AIH was （1.63±0.8） g/L,significantly lower than in patients with PBC[（4.49±1.2） g/L,P<0.05];The early diagnosis of AILD patients was difficult,and liver biopsy was the common cause of hospitalization in the newly diagnosed patients. There were a variety of reasons for hospitalization,among which cirrhosis complications accounted for the majority. The treatment programs were more individualized. Conclusions The conditions of the hospitalized patients with AILD are often complex,criticall and difficult in diagnosis and therapy. Liver biopsies is important and valuable for the diagnosis of AILD.

Key words: Autoimmune liver diseases, Clinical features, Liver biopsy, Therapy