云南省布朗族成人非酒精性脂肪性肝病流行特点研究*

doi:10.3969/j.issn.1672-5069.2022.02.018

实用肝脏病杂志 ›› 2022, Vol. 25 ›› Issue (2): 223-226.doi: 10.3969/j.issn.1672-5069.2022.02.018

云南省布朗族成人非酒精性脂肪性肝病流行特点研究^*

梁烨倍, 杨春光, 王昆凤, 胡秋明, 李妍辉, 罗琴, 陈浩, 郑亚雄, 余俊, 唐小英, 史华祥, 牛涛, 吴伟, 侯旭宏, 贾伟平

200233 上海市上海交通大学附属第六人民医院内分泌代谢科/上海市糖尿病临床医学中心/上海市糖尿病重点实验室/上海市糖尿病研究所(梁烨倍,杨春光,侯旭宏,贾伟平);云南省西双版纳傣族自治州西双版纳农垦医院医务科(王昆凤);检验科(胡秋明,罗琴,陈浩,郑亚雄,余俊);科教科(李妍辉);医院办公室(吴伟);勐海县布朗山乡卫生院(唐小英);勐海县人民医院医院办公室(史华祥,牛涛)

收稿日期:2021-05-12 出版日期:2022-03-10 发布日期:2022-03-15
通讯作者: 贾伟平,E-mail: wpjia@sjtu.edu.cn
作者简介:梁烨倍,女,29岁,博士研究生。E-mail: lyb2222@sjtu.edu.cn
基金资助:
*上海市自然科学基金资助项目(编号:18ZR1429000);上海市糖尿病重点实验室开放课题基金资助项目(编号:SHKLD-KF-1602)

Epidemiologic investigation of non-alcoholic fatty liver diseases in whole adults of Blang ethnicity in Yunnan province

Liang Yebei, Yang Chunguang, Wang Kunfeng, et al

Department of Endocrinology and Metabolism, Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Sixth People's Hospital, Affiliated to JiaoTong University, Shanghai 200233, China

Received:2021-05-12 Online:2022-03-10 Published:2022-03-15

摘要/Abstract

摘要： 目的调查云南省勐海县布朗族成人非酒精性脂肪性肝病(NAFLD)的流行特点及其它代谢性疾病的患病情况。方法 2017年2～3月对布朗族聚集且交通便利的5个行政村、18岁及以上3365名居民进行普查,纳入研究3258名。采用问卷调查、体格检查、实验室检测和超声检查。以2010年第六次全国人口普查的人口构成为标准人口构成,计算布朗族成人NAFLD的标化患病率。采用多因素Logistic回归分析NAFLD的患病因素。结果布朗族成人总体NAFLD标化患病率为16.7%,其中女性患病率为19.9%,显著高于男性的13.6%(x²=4.896,P<0.05);随着年龄的增长,人群和女性NAFLD患病率均呈上升趋势(P趋势<0.001);调整年龄、性别、文化程度、吸烟和饮酒后,多因素Logistic回归分析显示,超重/肥胖(OR:21.6,95% CI 16.8～27.9,P<0.05)、向心性肥胖(OR:14.2,95% CI 10.9～18.6,P<0.05)、高血压(OR:3.7,95% CI 2.8～4.9,P<0.05)、高甘油三酯血症(OR:3.6,95% CI 3.0～4.4,P<0.05)和糖尿病(OR:3.3,95% CI 2.4～4.4,P<0.05)患者患NAFLD的风险均显著高于他们的对照组。结论布朗族成人有较高的NAFLD患病率,NAFLD与肥胖的关联强度最强,布朗族成人肥胖管理是NAFLD及其它代谢紊乱性疾病管理的关键环节。

关键词: 非酒精性脂肪性肝病, 患病率, 流行病学调查, 布朗族

Abstract: Objective The aim of this study was to investigate the prevalence of non-alcoholic fatty liver diseases (NAFLD) and other metabolic diseases among whole adults of Blang ethnicity in Menghai county in Yunnan province. Methods A cross-sectional study with the census method was performed in this study. All residents of Blang ethnicity aged 18 or over from 5 administrative villages were recruited between February and March 2017. A total of 3365 individuals participated in this survey and eligible 3258 individuals with complete data were included. The data was obtained by questionnaires, physical examinations, blood assays and ultrasonography. The standardized prevalence was adjusted according to the sixth Chinese national census data in 2010. The multivariable Logistic regression was applied to reveal the risk factors for NAFLD. Results The overall standardized prevalence of NAFLD in our series was 16.7%, and of which, the prevalence of NAFLD in women was 19.9%, significantly higher than 13.6% in men (x²=4.896, P<0.05); the prevalence of NAFLD increased as the age increased among the overall population in among women (Ptrend<0.001); the multivariable Logistic regression analysis showed that when the age, gender, education, smoking, and drinking status adjusted, the likelihood of NAFLD in patients with overweight/obesity (OR: 21.6, 95% CI 16.8-27.9, P<0.05), central obesity (OR: 14.2, 95% CI 10.9-18.6, P<0.05), hypertension (OR: 3.7, 95% CI 2.8-4.9, P<0.05), hypertriglyceridemia (OR: 3.6, 95% CI 3.0-4.4, P<0.05), and diabetes (OR: 3.3, 95% CI 2.4-4.4, P<0.05)was significantly higher than that in their control group. Conclusion NAFLD is prevalent in Blang ethnic adults and the strongest association is found between obesity and NAFLD. The strict management of weight is a key measure to prevent NAFLD and other metabolic diseases in Blang ethnic adults.

Key words: Non-alcoholic fatty liver diseases, Prevalence, Epidemiologic investigation, Blang nationality

梁烨倍, 杨春光, 王昆凤, 胡秋明, 李妍辉, 罗琴, 陈浩, 郑亚雄, 余俊, 唐小英, 史华祥, 牛涛, 吴伟, 侯旭宏, 贾伟平. 云南省布朗族成人非酒精性脂肪性肝病流行特点研究^*[J]. 实用肝脏病杂志, 2022, 25(2): 223-226.

Liang Yebei, Yang Chunguang, Wang Kunfeng, et al. Epidemiologic investigation of non-alcoholic fatty liver diseases in whole adults of Blang ethnicity in Yunnan province[J]. Journal of Practical Hepatology, 2022, 25(2): 223-226.

参考文献

[1] Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease:meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology, 2016, 64(1):73-84.
[2] Estes C, Anstee QM, Arias-Loste MT, et al. Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030. J Hepatol, 2018, 69(4):896-904.
[3] Mantovani A, Petracca G, Beatrice G, et al. Non-alcoholic fatty liver disease and risk of incident diabetes mellitus: an updated meta-analysis of 501 022 adult individuals. Gut, 2021, 70(5):962-969.
[4] Ballestri S, Zona S, Targher G, et al. Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis. J Gastroenterol Hepatol, 2016, 31(5):936-944.
[5] Targher G, Byrne CD, Lonardo A, et al. Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: a meta-analysis. J Hepatol, 2016, 65(3):589-600.
[6] Mantovani A, Petracca G, Beatrice G, et al. Non-alcoholic fatty liver disease and risk of incident chronic kidney disease: an updated meta-analysis. Gut, 2020.
[7] 高国一,杨玲,姜范波,等. 西双版纳州2006年人口较少民族成人健康检查结果分析. 实用预防医学,2009,16(3):710-712.
[8] 梁烨倍,侯旭宏,吴伟,等. 布朗族成人糖尿病患病率及其影响因素研究. 中华内科杂志,2019,58(1):27-32.
[9] Farrell GC, Chitturi S, Lau GK, et al. Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary. J Gastroenterol Hepatol, 2007, 22(6):775-777.
[10] European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO).EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease. J Hepatol, 2016, 64(6):1388-1402.
[11] 中华医学会肝病学分会脂肪肝和酒精性肝病学组,中国医师协会脂肪肝专家委员会.酒精性肝病防治指南(2018年更新版).实用肝脏病杂志,2018,21(2): 170-176.
[12] 中国肥胖问题工作组数据汇总分析协作组. 我国成人体质量指数和腰围对相关疾病危险因素异常的预测价值:适宜体质量指数和腰围切点的研究. 中华流行病学杂志,2002,23(1):5-10.
[13] Jia W, Weng J, Zhu D, et al. Standards of medical care for type 2 diabetes in China 2019. Diabetes Metab Res Rev, 2019, 35(6):e3158.
[14] 中国高血压防治指南修订委员会,高血压联盟中华医学会心血管病学分会,中国医师协会高血压专业委员会. 中国高血压防治指南(2018年修订版). 中国心血管杂志,2019,24(1):24-56.
[15] 中国成人血脂异常防治指南修订联合委员会. 中国成人血脂异常防治指南(2016年修订版). 中华心血管病杂志,2016,44(10):833-853.
[16] Hu X, Huang Y, Bao Z, et al. Prevalence and factors associated with nonalcoholic fatty liver disease in Shanghai work-units. BMC Gastroenterol, 2012, 12:123.
[17] Yang CQ, Shu L, Wang S, et al. Dietary patterns modulate the risk of non-alcoholic fatty liver disease in Chinese adults. Nutrient, 2015, 7(6):4778-4791.
[18] Dai H, Wang W, Chen R, et al. Lipid accumulation product is a powerful tool to predict non-alcoholic fatty liver disease in Chinese adults. Nutr Metab, 2017, 14:49.
[19] Sanyal AJ. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology, 2002, 123(5):1705-1725.
[20] Lin S, Xian Y, Liu Y, et al. Risk factors and community intervention for nonalcoholic fatty liver disease in community residents of Urumqi, China. Medicine, 2018, 97(9):e0021.
[21] Buzzetti E, Pinzani M, Tsochatzis EA. The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism, 2016, 65(8):1038-1048.

云南省布朗族成人非酒精性脂肪性肝病流行特点研究^*

Epidemiologic investigation of non-alcoholic fatty liver diseases in whole adults of Blang ethnicity in Yunnan province

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