关键词: 非酒精性脂肪性肝病, 中药, 氧化应激, 治疗

Abstract: Objective To observe the short-term efficacy of herbal medicine in treatment of patients with nonalcoholic fatty liver disease （NAFLD）. Methods 100 patients with NAFLD were recruited in our hospital between January 2015 and January 2017,and were randomly divided into the observation（n=50） and the control group （n=50） by office-software-generated randomized number. The patients in control were guided for food and exercise modulation,and the patients in observation were given herbal medicine for 8 weeks. Serum total antioxidant capacity （T-AOC）,superoxide dismutase （SOD）,malondialdehyde （MDA）,and nitric oxide （NO） level were detected by ELISA,and serum fasting blood glucose （FBG） as well as fasting insulin （FINS） were assayed to calculate the insulin resistance index （HOMA IR）. Results At the end of 8-week treatment,serum ALT,AST and GGT levels in the observation were （65.1±7.8）U/L,（69.4±8.5）U/L and （95.4±12.3） U/L,significantly lower than（94.1±12.3） U/L,（99.3±8.6） U/L and （141.9±15.7）U/L,respectively,in the control （P<0.05）;serum T-AOC,SOD,NO and MDA levels were（38.1±5.1） U/ml,（89.1±12.1） μg/ml,（20.1±1.8） mg/L and（8.4±1.1）ng/ml,significantly different as compared to （25.1±3.2） U/ml,（62.1±6.9） μg/ml,（13.1±1.2） mg/L and （12.0±1.2） ng/ml in the control （P<0.05）;serum FBG,HOMA-IR, TC and TG levels were（6.1±1.2） mmol/L,（5.8±0.9）,（2.2±0.1） mmol/L and（0.4±0.1） mmol/L,significantly lower than （6.8±2.3） mmol/L,（6.4±1.9）,（2.7±0.3） mmol/L and（0.7±0.3） mmol/L,respectively,in the control（P<0.05）. Conclusion The application of herbal medicine in the treatment of patients with NAFLD might have a short-term efficacy,which could decrease serum liver enzymes and regulate the glycolipid metabolism.

Key words: Non-alcoholic fatty liver disease, Herbal medicine, Oxidative stress, Therapy