关键词: 肝硬化, 败血症, 革兰氏阴性杆菌, 危险因素

Abstract: Objective To investigate the clinical features and risk factors of patients with decompensated cirrhosis and sepsis.Methods 68 patients with decompensated liver cirrhosis were enrolled in our hospital between 2014 and 2018,and 30 patients were diagnosed with sepsis. Logistic regression analysis was applied to find the affecting risk factors for the occurrence of sepsis.Results Out of the 30 patients with sepsis,30 cases of pathogenic bacteria were detected,including 19 cases of gram-negative bacteria （Klebsiella pneumonia in 8,E. Coli in 6,and 5 cases of other gram-negative bacteria）. Eleven cases of gram-positive bacteria were detected （Staphylococcus aureus in 5,Streptococcus viridians in 2 and 4 cases of other gram-positive bacteria）. In patients with sepsis,the percentage of neutrophil was（74.34±2.88） %,blood creatinine level was （126.57±20.81） μmol/L,CRP was（48.93±10.28） mg/l,serum bilirubin level was（82.29±16.59） μmol/L,all significantly different compared to [（58.53±2.91）%,（74.69±3.24） μmol/L,（24.21±6.66） mg/l and（52.93±11.03） μmol/L,P<0.05] in patients without sepsis,while serum albumin level was （27.21±5.66） g/L,much lower than 【（31.83±7.98） g/L,P<0.05】 in the control;Logistic regression analysis showed that serum bilirubin and albumin levels were the independent risk factors for the occurrence of sepsis. Conclusion The common pathogen in deconpensated liver cirrhosis patients with sepsis is gram-negative bacillus,and the clinicians should take risk factors into consideration in this settings.

Key words: Liver cirrhosis, Sepsis, Gram-negative bacillus, Risk factors