关键词: 肝硬化, 院内感染, 危险因素, 多元回归分析

Abstract: Objective To analyze the risk factors of nosocomial infections in patients with hepatitis B liver cirrhosis. Methods 280 patients with hepatitis B liver cirrhosis were recruited in our hospital between January 2015 and January 2017,and the diagnosis of infections was carried out according to the clinical,blood,bacteria culture and imaging results. The independent risk factors of acquired infection were analyzed by Logistic regression analysis. Results Out of the 280 patients with liver cirrhosis, the nosocomial infections occurred in 57（20.4%）,including spontaneous bacteria peritonitis in 18（31.6%）,respiratory infection in 12（21.1%）,gut infection in 10（17.5%）,urological infection in 7（12.3%）and septicemia in 10（17.5%）;univariate analysis showed that age （x²=7.416,P=0.006）,hospital stay（t=28.247,P<0.001）,serum albumin （t=2.661,P=0.008）,ATP of peripheral blood CD4⁺T lymphocyte （t=8.122,P<0.001）,Child-Pugh score（x²=10.577,P=0.005）,invasive manipulation （x²=29.214,P<0.001）,ascites （x²=25.776,P<0.001） and gastrointestinal bleeding （x²=111.434,P<0.001） were,while the gender and hepatic encephalopathy were not（P>0.05）,the risk factors for acquired infections;multivariate Logistic analysis demonstrated that age,invasive manipulation,ascites,gastrointestinal bleeding,hospital stay and serum albumin level were the independent risk factors for the nosocomial infections in these patients. Conclusion Patients with liver cirrhosis are susceptible to nosocomial infections,especially in those with elderly age,lower serum albumin level and long hospital stay,and the clinicians should pay attention to them and eliminate the risk factors of nosocomial acquired infection.

Key words: Liver cirrhosis, Nosocomial infections, Risk factors, Logistic analysis