UCAM和Maria诊断标准用于评估1352例中国人药物性肝损伤文献分析

doi:10.3969/j.issn.1672-5069.2018.06.014

实用肝脏病杂志 ›› 2018, Vol. 21 ›› Issue (6): 881-884.doi: 10.3969/j.issn.1672-5069.2018.06.014

UCAM和Maria诊断标准用于评估1352例中国人药物性肝损伤文献分析

孙文静, 陈东风

400042 重庆市第三军医大学大坪医院野战外科研究所消化内科

收稿日期:2017-10-17 出版日期:2018-11-10 发布日期:2018-12-25
通讯作者: 陈东风,E-mail: chendf1981@126.com
作者简介:孙文静,女,34岁,硕士研究生,主治医师。主要从事慢性肝病的诊治研究。E-mail: fountaincs@163.com

Literature analysis about RUCAM scale and Maria scale in diagnosis of Chinese patients with drug-induced liver injury

Sun Wenjing, Chen Dongfeng.

Department of Gastroenterology,Research Institute of Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,China

Received:2017-10-17 Online:2018-11-10 Published:2018-12-25

摘要/Abstract

摘要： 目的分析文献应用RUCAM标准和Maria标准诊断中国人药物性肝损伤情况。方法以“药物性肝损伤、诊断标准、诊断评分系统或drug-induced liver injury,diagnostic criteria, diagnostic scale, RUCAM scale, Maria scale”为关键词检索中国期刊全文数据库、万方数据库、pubmed数据库,排除文献综述、重复文献、病例报道、未使用诊断标准或诊断评分系统进行诊断的文献,对文献中患者年龄、性别、诊断标准的诊断评估情况进行总结和描述。结果在检索到的7篇文献中,共有1352例药物性肝损伤患者,年龄2~91岁。采用RUCAM诊断标准者6篇,共1027例病例,诊断DILI 997例（97.1%）,不能诊断DILI者有30例（2.9%）;采用Maria诊断标准诊断者4篇,共736例病例,诊断DILI者433例（58.8%）,不能诊断DILI者303例（41.2%）。结论应用RUCAM诊断标准或Maria诊断标准诊断中国人药物性肝损伤的结果存在不一致性。

关键词: 药物性肝损伤, RUCAM诊断标准, Maria诊断标准, 文献分析

Abstract: Objective To summarize the diagnostic value of two diagnostic criteria in diagnosis of patients with drug-induced liver injury（DILI） in Chinese population. Methods We searched publications about Chinese patients in journal full-text database,Wanfang database and pubmed database with keywords of drug-induced liver injury,diagnostic criteria,diagnostic scoring system,RUCAM and Maria scale. Literature review,case reports,and duplication data were excluded. Age,gender and diagnostic criteria were summarized. Results A total of 7 papers including 1352 patients with DILI were included in this analysis. The age range of the patients in this series was 2 to 91 years old. Six papers having 997 cases （97.1%） were diagnosed as DILI,and 30 cases （2.9%） were not diagnosed as DILI by RUCAM scale. Four papers having 736 cases（58.8%） were diagnosed as DILI,and 303 cases（41.2%） were not diagnosed as DILI by Maria scale. Conclusion The diagnostic results of DILI by RUCAM scale and Maria scale were not the same sometimes,which warrants further study.

Key words: Drug-induced liver injury, RUCAM scale, Maria scale, Literature review

孙文静, 陈东风. UCAM和Maria诊断标准用于评估1352例中国人药物性肝损伤文献分析[J]. 实用肝脏病杂志, 2018, 21(6): 881-884.

Sun Wenjing, Chen Dongfeng.. Literature analysis about RUCAM scale and Maria scale in diagnosis of Chinese patients with drug-induced liver injury[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2018, 21(6): 881-884.

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UCAM和Maria诊断标准用于评估1352例中国人药物性肝损伤文献分析

Literature analysis about RUCAM scale and Maria scale in diagnosis of Chinese patients with drug-induced liver injury

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