关键词: 药物性肝损伤, 胺碘酮, 不良反应

Abstract: Objective To summarize the clinical characteristics of amiodarone-induced acute liver injury. Method 23 patients with acute liver injury after intravenous administration of amiodarone were selected in our hospital between February 2010 and February 2016. The underlying diseases,medical regimen,the use of amiodarone indications,combined medication,the time of liver damage,liver function recovery and outcome were recorded. Results After intravenous administration of amiodarone,2 cases （8.7%） showed liver damage in 8 h, 8 cases （34.8%） hade liver damage between 9~48 h,5 cases （8.7%） with 49~72 h,7 cases （30.4%） in 73~96 h,1 cases （4.3%） after 96 h;serum aspertate aminotransferase levels peaked up at 17468 U/L,with average of （3648±3889） U/L,alanine aminotransferase peaked up at 13437 U/L,with average of（3142±1846） U/L,and 15 cases（63.2%） had jaundice;19 patients recovered with liver function back to normal within 2~91 days,and the average time was（33.76±19.38） days after withdrawal of amiodarone and having an active treatment,1 patients died of cardiac shock,2 patients died of acute liver and kidney insufficiency and 1 patients died of hepatic encephalopathy. Conclusion The specific mechanism of liver damage by amiodarone is not yet clear,and we can not completely eliminate the effect of other medications on the liver function abnormal,but there is no doubt that amiodarone is an important factor causing liver damage.

Key words: Drug-induced liver injury, Amiodarone, Untoward effect