球囊阻断逆行经静脉闭塞术治疗乙型肝炎肝硬化并发胃静脉曲张患者疗效研究*

doi:10.3969/j.issn.1672-5069.2026.01.021

实用肝脏病杂志 ›› 2026, Vol. 29 ›› Issue (1): 81-84.doi: 10.3969/j.issn.1672-5069.2026.01.021

球囊阻断逆行经静脉闭塞术治疗乙型肝炎肝硬化并发胃静脉曲张患者疗效研究^*

段后张, 郑扬, 陈旭峰, 汤小龙, 汪程龙

214000 江苏省无锡市解放军联勤保障部队第904医院消化内科(段后张,郑扬,陈旭峰,汤小龙);南京医科大学第三附属医院消化内科(汪程龙)

收稿日期:2025-07-02 出版日期:2026-01-10 发布日期:2026-02-04
通讯作者: 汤小龙,E-mail:413992264@qq.com
作者简介:段后张,男,30岁,大学本科,住院医师。E-mail:17602123346@163.com
基金资助:
^*江苏省科技厅社会发展面上基金资助项目(编号:BE2020775)

Efficacy of balloon-occluded retrograde transvenous obliteration in the treatment of patients with hepatitis B-induced liver cirrhosis and gastric varices

Duan Houzhang, Zheng Yang, Chen Xufeng, et al

Department of Gastroenterology, 904^th Hospital, Joint Logistics Support Force, Wuxi 214000, Jiangsu Province, China

Received:2025-07-02 Online:2026-01-10 Published:2026-02-04

摘要/Abstract

摘要： 目的比较研究球囊阻断逆行经静脉闭塞术(BRTO)与经颈静脉肝内门体分流术(TIPS)治疗乙型肝炎肝硬化并发胃静脉曲张(GV)患者的疗效和安全性。方法 2022年1月～2024年6月我院收治的乙型肝炎肝硬化并发GV患者101例,被随机分为观察组51例和对照组50例,分别接受BRTO或TIPS治疗,随访12个月。结果在随访3月时,观察组GV根除率为84.3%,再次行BRTO治疗后,GV全部被根除(100.0%)。对照组GV消失率为10.0%(P<0.05);在随访6月时,观察组死亡2例,对照组死亡4例;在随访12月时,观察组死亡3例,对照组死亡5例;术后,两组血常规和肝功能指标无显著改善,两组指标变化无统计学差异(P>0.05)。结论采取BRTO治疗乙型肝炎肝硬化并发GV患者,手术技术要求高,消除GV效果确实,其在防治食管胃底静脉曲张破裂出血方面的效果还需要观察。

关键词: 肝硬化, 胃静脉曲张, 球囊阻断逆行经静脉闭塞术, 经颈静脉肝内门体分流术, 治疗

Abstract: Objective This study aimed to retrospectively evaluate the efficacy and safety of balloon-occluded retrograde transvenous obliteration (BRTO) in patients with hepatitis B-induced liver cirrhosis (LC) complicated by gastric varices (GV). Methods A total of 101 patients with hepatitis B-induced LC and complicated GV were encountered in our hospital between January 2022 and June 2024, and were randomly divided into two groups, underwent BRTO in observation group (n=51) or transjugular intrahepatic portosystemic shunt (TIPS) in control group (n=50). All patients were followed-up for one year after operation. Results By end of three-month of follow-up, eradication rate of GV in the observation group was 84.3% and second BRTO eradicated all GV, while GV disappeared in 5 cases (10.0%, P<0.05) in the control; by end of six-month of follow-up, two patients in the observation and four patients in the control died; by end of one-year of follow-up, three cases in BRTO-treated patients and five cases in TIPS-treated died; after operations, the liver function tests and hypersplenism didn’t improved and the related parameter were not significantly different between the two groups(P>0.05). Conclusion BRTO demonstrates safe and a favorable GV eradication rate in the treatment of patients with hepatitis B-induced LC, which might needs sophisticated procedural skills, and the long-term efficacy on prophylactic GV bleeding is still observed.

Key words: Liver cirrhosis, Gastric varices, Balloon-occluded retrograde transvenous obliteration, Transjugular intrahepatic portosystemic shunt, Therapy

段后张, 郑扬, 陈旭峰, 汤小龙, 汪程龙. 球囊阻断逆行经静脉闭塞术治疗乙型肝炎肝硬化并发胃静脉曲张患者疗效研究^*[J]. 实用肝脏病杂志, 2026, 29(1): 81-84.

Duan Houzhang, Zheng Yang, Chen Xufeng, et al. Efficacy of balloon-occluded retrograde transvenous obliteration in the treatment of patients with hepatitis B-induced liver cirrhosis and gastric varices[J]. Journal of Practical Hepatology, 2026, 29(1): 81-84.

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球囊阻断逆行经静脉闭塞术治疗乙型肝炎肝硬化并发胃静脉曲张患者疗效研究^*

Efficacy of balloon-occluded retrograde transvenous obliteration in the treatment of patients with hepatitis B-induced liver cirrhosis and gastric varices

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