关键词: 肝硬化, 乙型肝炎, 空腹血糖受损, 糖耐量受损, 糖尿病, 影响因素

Abstract: Objective The aim of this study was to investigate prevalence and impacting factors of abnormal glucose metabolism in patients with chronic hepatitis B (CHB) and hepatitis B-induced liver cirrhosis (LC). Methods 329 patients with CHB and 258 patients with hepatitis B-induced LC were encountered in our hospital between October 2021 and October 2024, and clinical materials were collected routinely. Binary Logistic regression analysis was adopted to analyze the factors impacting abnormal glucose metabolism in patients with CHB and LC. Results Prevalence of abnormal glucose metabolism in our series was 54.2%, with impaired fasting glucose (IFG) of 3.7%, impaired glucose tolerance (IGT) of 23.2% and diabetes mellitus (DM) of 27.3%; incidence of IFG and IGT in patients with LC were 5.0% and 23.6%, both not significantly different as compared to 2.7% and 22.8% in those with CHB (P>0.05), while incidence of DM was 35.7%, much higher than 20.7%(P<0.05) in patients with CHB; ages, body mass index (BMI), percentages of alcohol abuse, concomitant blood hypertension, hyperlipidemia and LC in 318 patients with abnormal glucose metabolism were(51.2±13.6)yr, (25.8±3.4)kg/m², 40.3%, 25.8%, 21.4% and 64.3%, all significantly greater or higher than [(40.3±9.3)yr, (23.6±3.1)kg/m², 28.3%, 14.9%, 9.7% and 34.2, respectively, P<0.05] in 269 patients with normal glucose metabolism; binary Logistic regression analysis showed that age, alcohol abuse, blood hypertension, hyperlipidemia and LC were all the risk factors impacting glucose metabolism in patients with CHB and LC (P<0.05). Conclusion The incidence of abnormal glucose metabolism in patients with CHB and LC is high, and patients with old age, alcohol abuse, concomitant hypertension, hyperlipidemia and LC are susceptible, which should be carefully screened and managed.

Key words: Liver cirrhosis, Hepatitis B, Impaired fasting glucose, Impaired glucose tolerance, Diabetes mellitus, Influencing factors