超声特征联合血清ROMO1和AFP诊断儿童肝母细胞瘤价值研究*

doi:10.3969/j.issn.1672-5069.2025.06.030

摘要/Abstract

摘要： 目的探讨超声特征联合血清活性氧调节因子1(ROMO1)和甲胎蛋白(AFP)水平诊断儿童肝母细胞瘤(HB)的价值。方法 2022年1月～2025年1月我院收治的肝脏局灶性病变(FLL)患儿112例,均接受超声检查及术后组织病理学检查。采用ELISA检测血清ROMO1水平,采用化学发光法检测血清AFP水平,采用受试者工作特征(ROC)曲线分析超声特征联合血清ROMO1和AFP水平鉴别诊断儿童HB的效能。结果在本组112例FLL儿童中,术后组织病理学诊断HB者78例和良性病变34例;HB病灶直径、形态不规则和局部浸润占比分别为(9.2±2.3)cm、51.3%和35.9%,均显著大于或高于良性病变组【(1.6±0.6)cm、10.3%和0.0%,P<0.05】;HB组血清AFP和ROMO1水平分别为(156.4±24.5)ng/mL和(130.1±20.1)ng/mL,均显著高于良性组【分别为(7.1±2.4)ng/mL和(19.0±3.7)ng/mL,P<0.05】;ROC曲线分析表明,应用超声检测的肿瘤直径和形态不规则联合血清AFP和ROMO1水平诊断儿童HB的AUC为0.867,其诊断的敏感度为96.2%,特异度为64.7%,具有临床应用价值。结论应用超声检查联合血清ROMO1和AFP水平检测可为临床早期精准鉴别儿童HB提供可靠的诊断手段。

关键词: 肝母细胞瘤, 超声特征, 活性氧调节因子1, 甲胎蛋白, 儿童, 诊断

Abstract: Objective The aim of this study was to investigate diagnostic performance of ultrasound features in combination with serum reactive oxygen species modulator 1 (ROMO1)and alpha-fetoprotein (AFP) levels in children with hepatoblastoma (HB). Methods 112 children with focal liver lesions (FLL) were encountered in our hospital between January 2022 and January 2025, and they all received ultrasonography. Serum ROMO1 level was detected by ELISA, and serum AFP level was detected by chemiluminescence. Receiver operating characteristic (ROC) curve was applied to evaluate diagnostic efficacy. Results Of the 112 children with FLL, the histo-pathological examination found HB in 78 cases and benign lesions in 34 cases; diameter of tumors, percentages of irregular lesion and local infiltration in children with HB were(9.2±2.3)cm, 51.3% and 35.9%, all significantly greater or higher than [(1.6±0.6)cm, 10.3% and 0.0%, respectively, P<0.05] in benign lesions; serum AFP and ROMO1 levels in patients with HB were (156.4±24.5)ng/mL and (130.1±20.1)ng/mL, both significantly higher than [(7.1±2.4)ng/mL and (19.0±3.7)ng/mL, respectively, P<0.05] in those with benign lesions; ROC analysis showed that the AUC was 0.867, with sensitivity of 96.2% and specificity of 64.7%, when ultrasonic features in combination with serum AFP and ROMO1 levels in diagnosing HB in children. Conclusion Ultrasound features in combination with serum ROMO1 and AFP levels could provide a more reliable auxiliary tool for early accurate identification of HB in children.

Key words: Hepatoblastoma, Ultrasonography, Reactive oxygen species modulator 1, Alpha-fetoprotein, Diagnosis, Children

何倩, 张瑞, 史莉玲, 张莹. 超声特征联合血清ROMO1和AFP诊断儿童肝母细胞瘤价值研究^*[J]. 实用肝脏病杂志, 2025, 28(6): 918-921.

He Qian, Zhang Rui, Shi Liling, et al. Diagnostic performance of ultrasound features in combination with serum reactive oxygen species modulator 1 and alpha-fetoprotein levels in children with hepatoblastoma[J]. Journal of Practical Hepatology, 2025, 28(6): 918-921.

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超声特征联合血清ROMO1和AFP诊断儿童肝母细胞瘤价值研究^*

Diagnostic performance of ultrasound features in combination with serum reactive oxygen species modulator 1 and alpha-fetoprotein levels in children with hepatoblastoma

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