122例肝脓肿患者临床特征和病原菌分析*

doi:10.3969/j.issn.1672-5069.2025.06.031

实用肝脏病杂志 ›› 2025, Vol. 28 ›› Issue (6): 922-925.doi: 10.3969/j.issn.1672-5069.2025.06.031

122例肝脓肿患者临床特征和病原菌分析^*

张倩, 丁蓉, 姬文莉

211102 南京市东南大学医学院附属南京同仁医院医学检验科

收稿日期:2025-08-10 出版日期:2025-11-10 发布日期:2025-11-13
通讯作者: 姬文莉,E-mail:787003637@qq.com
作者简介:张倩,女,35岁,大学本科,主管检验师。E-mail:zhangqian46839@163.com
基金资助:
^*江苏省科技厅科研基金资助项目(编号:Z2024088)

Clinical feature, pathogen distribution and prognosis in patients with pyogenic liver abscess

Zhang Qian, Ding Rong, Ji Wenli

Clinical Laboratory, Tongren Hospital, Southeast University School of Medicine, Nanjing 211102, Jiangsu Province, China

Received:2025-08-10 Online:2025-11-10 Published:2025-11-13

摘要/Abstract

摘要： 目的观察并分析细菌性肝脓肿(PLA)患者临床特征、病原菌分布和预后情况。方法 2022年4月~2025年4月我院收治的PLA患者122例,给予抗生素、穿刺抽脓或置管引流治疗。使用法国生物梅里埃公司的 VITEK 2 Compact 全自动微生物鉴定仪进行病原菌鉴定。结果 122例PLA患者脓肿直径为(4.8±0.9)cm,外周血WBC计数为(13.6±2.5)×10⁹/L,血清CRP水平为(124.2±26.8)mg/L,PCT为(4.8±1.2)ng/mL;主要基础疾病为糖尿病占42.6%,胆道疾病占45.9%;脓肿位于肝右叶占62.3%,单发脓肿占74.6%;主要病原菌为肺炎克雷伯菌46株(45.1%),大肠埃希菌18株(17.6%)和金黄色葡萄球菌12株(11.8%);在治疗2～6周[平均为(3.5±0.8)周]后,122例PLA患者死亡2例,其他患者均治愈。结论 PLA患者主要基础疾病为糖尿病和胆道疾病,肺炎克雷伯菌为最主要的病原菌,合并糖尿病容易发生PLA。大多患者预后良好。

关键词: 肝脓肿, 临床特征, 病原菌, 预后

Abstract: Objective The aim of this study was to observe clinical feature, pathogen distribution and prognosis in patients with pyogenic liver abscess (PLA). Methods A total of 122 patients with PLA were admitted to our hospital between April 2022 and April 2025, and all were treated by percutaneous catheter drainage (PCD) and intravenous antibiotics. The pathogens identification was performed by full-automatic microbial identification instrument. Results The diameter of abscess was(4.8±0.9)cm, WBC count was (13.6±2.5)×10⁹/L, serum CRP level was (124.2±26.8)mg/L and serum procalcitonin level was (4.8±1.2)ng/mL; underlying diseases, such as diabetes accounted for 42.6% and biliary tract diseases for 45.9%; abscess located at right lobe accounted for 62.3% and single abscess for 74.6%; main pathogens were Kleebsiella pneumoniae (45.1%), Escherichia coli (17.6%) and Staphylococcus aureus (11.8%); after 2 to 6, with average of (3.5±0.8)week treatment, two patients with PLA died of septic shock or multiple organ failure, and other 120 patients with PLA recovered. Conclusion In patients with PLA, the main underlying diseases are diabetes mellitus and biliary tract diseases, common pathogens are Klebsiella pneumoniae, and the prognosis of patients with PLA are satisfactory.

Key words: Pyogenic liver abscess, Clinical feature, Pathogen, Prognosis

张倩, 丁蓉, 姬文莉. 122例肝脓肿患者临床特征和病原菌分析^*[J]. 实用肝脏病杂志, 2025, 28(6): 922-925.

Zhang Qian, Ding Rong, Ji Wenli. Clinical feature, pathogen distribution and prognosis in patients with pyogenic liver abscess[J]. Journal of Practical Hepatology, 2025, 28(6): 922-925.

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122例肝脓肿患者临床特征和病原菌分析^*

Clinical feature, pathogen distribution and prognosis in patients with pyogenic liver abscess

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