吲哚菁绿荧光显像指导腹腔镜胆囊切除术治疗胆囊良性疾病患者效果研究*

doi:10.3969/j.issn.1672-5069.2023.05.036

实用肝脏病杂志 ›› 2023, Vol. 26 ›› Issue (5): 746-749.doi: 10.3969/j.issn.1672-5069.2023.05.036

吲哚菁绿荧光显像指导腹腔镜胆囊切除术治疗胆囊良性疾病患者效果研究^*

宋巍, 李智德, 李玉鹏, 陈雄

830000 乌鲁木齐市新疆维吾尔自治区人民医院肝胆外科

收稿日期:2022-11-25 出版日期:2023-09-10 发布日期:2023-09-13
通讯作者: 陈雄,E-mail:nhcx123@126.com
作者简介:宋巍,男,38岁,博士研究生,副主任医师。主要从事肝脏胰外科基础与临床研究。E-mail:song1012@126.com
基金资助:
^*新疆维吾尔自治区科技厅天山创新团队科研计划项目(编号:202116770)

Laparoscopic cholecystectomy under guidance of indocyanine green fluorescence imaging in treatment of patients with benign gallbladder diseases

Song Wei, Li Zhide, Li Yupeng, et al

Department of Hepatobiliary Surgery, Provincial People's Hospital, Urumchi 830000, Xinjiang Uygur Autonomous Region, China

Received:2022-11-25 Online:2023-09-10 Published:2023-09-13

摘要/Abstract

摘要： 目的探讨吲哚菁绿(ICG)荧光显像技术在腹腔镜胆囊切除术(LC)中的应用价值。方法 2021年10月～2022年7月我科收治的 62 例胆囊良性疾病患者,被分为两组,分别行ICG荧光导航LC或普通LC术。结果两组均顺利完成手术,术中均未发生医源性胆道损伤,对照组发生中转开腹1例(3.2%);荧光LC组辨识胆总管和胆囊管时间、分离出胆囊管和胆囊动脉时间、胆囊切除总用时和术中出血量分别为0.5(0.5,1)min、(16.9±0.4)min、30(28,33)min和15(5,20)ml,显著短于或少于对照组【分别为2(1,3)min、(24.9±0.1)min、46(39,53)min和30(20,40)ml,P< 0.05】;两组术后并发症发生率比较,无显著性差异(0.0%对3.2%,P>0.05)。结论采用ICG荧光导航LC手术是一种非常有用的辅助工具,其实时显像辨别胆道解剖结构,提高了手术效率,减少了医源性胆道损伤,缩短了手术时间。

关键词: 胆囊结石, 慢性胆囊炎, 腹腔镜胆囊切除术, 吲哚菁绿, 荧光导航, 治疗

Abstract: Objective The purpose of this study was to investigate the application of indocyanine green(ICG) fluorescence imaging in laparoscopic cholecystectomy(LC) in the treatment of patients with benign gallbladder diseases. Methods 62 patients with benign gallbladder diseases, such as cholecystolithiasis and chronic cholecystitis, etc, were encountered in our hospital between October 2021 and July 2022, and were divided into two groups, with 31 cases in each, underwent LC under ICG fluorescent navigation or routine operation. Results The operation was successfully completed, and no iatrogenic biliary duct injury occurred in the two groups; one patient (3.2%)in the control group was transferred to open laparotomy; the time of identification and complete anatomic isolation of three tubes, operation time and intraoperative blood loss in the fluorescent navigation group were 0.5(0.5, 1)min, (16.9±0.4)min, 30(28, 33)min and 15(5, 20)ml, all significantly shorter or less than [2(1, 3)min, (24.9±0.1)min, 46(39, 53)min and 30(20, 40)ml, respectively, P< 0.05] in routine operation group; there was no significant difference respect to post-operational complications in the two groups (0.0% vs. 3.2%, P>0.05). Conclusion The ICG fluorescence navigation during LC is a very good measure, especially in difficult surgeries, which might be helpful to identify the anatomical structure of biliary duct, shorten operation times and reduce iatrogenic bile duct injury.

Key words: Cholecystolithiasis, Chronic cholecystitis, Laparoscopic cholecystectomy, Indocyanine green, Fluorescence navigation, Therapy

宋巍, 李智德, 李玉鹏, 陈雄. 吲哚菁绿荧光显像指导腹腔镜胆囊切除术治疗胆囊良性疾病患者效果研究^*[J]. 实用肝脏病杂志, 2023, 26(5): 746-749.

Song Wei, Li Zhide, Li Yupeng, et al. Laparoscopic cholecystectomy under guidance of indocyanine green fluorescence imaging in treatment of patients with benign gallbladder diseases[J]. Journal of Practical Hepatology, 2023, 26(5): 746-749.

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吲哚菁绿荧光显像指导腹腔镜胆囊切除术治疗胆囊良性疾病患者效果研究^*

Laparoscopic cholecystectomy under guidance of indocyanine green fluorescence imaging in treatment of patients with benign gallbladder diseases

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