[1] 周新民,丁小鹏. 基础肝病治疗在原发性肝癌综合治疗中的重要作用.实用肝脏病杂志,2021,24(1),4-6. [2] Llovet J M,Kelley R K,Villanueva A,et al. Hepatocellular carcinoma. Nat Rev Dis Prim,2021, 7(1):6. [3] D'arcy M S.Cell death: a review of the major forms of apoptosis, necrosis and autophagy.Cell Biology Int, 2019,43(6):582-592. [4] Pasparakis M,Vandenabeele P.Necroptosis and its role in inflammation.Nature,2015,517(7534):311-320. [5] Simon N,Friedman J,Hastie T,et al.Regularization paths for Cox's proportional hazards model via coordinate descent.J Statist Softw,2011,39(5):1-13. [6] Tibshirni R.The lasso method for variable selection in the Cox model.Statist Med,1997,16(4):385-395. [7] 赵艺,卢秉久.基于TCGA数据库分析肝细胞癌组织UCK2、PRIM1和DNTM1基因水平对患者预后的影响.实用肝脏病杂志,2021,24(5):729-732. [8] Horn-Ghetko D,Krist D T,Prabu J R,et al.Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.Nature,2021,590(7847):671-676. [9] Vanden Berghe T,Linkermann A,Jouan-lanhouet S,et al.Regulated necrosis: the expanding network of non-apoptotic cell death pathways.Nat Rev Mol Cell Biol,2014,15(2):135-147. [10] Lamkanfi M,Dixit V M.Mechanisms and functions of inflammasomes.Cell,2014,157(5):1013-1022. [11] Gautheron J,Vucur M,Reisinger F,et al.A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis.EMBO Mol Med,2014,6(8):1062-1074. [12] Roychowdhury S,Mcmullen M R,Pisano S G,et al.Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury.Hepatology (Baltimore, Md),2013,57(5):1773-1783. [13] Gong Y,Fan Z,Luo G,et al.The role of necroptosis in cancer biology and therapy.Mol Cancer,2019,18(1):100. [14] Yang T B,Yi F,Liu W F,et al.Identification of hsa_circ_0039053 as an up-regulated and oncogenic circRNA in hepatocellular carcinoma via the miR-637-mediated USP21 activation.J Cancer,2020,11(23):6950-6959. [15] Pannu J,Belle J I,Förster M,et al.Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation.PLoS One,2015,10(2):e0117304. [16] Duran A,Hernandez E D,Reina-campos M,et al.p62/SQSTM1 by binding to vitamin D receptor inhibits hepatic stellate cell activity, fibrosis, and liver cancer.Cancer cell,2016,30(4):595-609. [17] Shi W,Feng L,Dong S,et al.FBXL6 governs c-MYC to promote hepatocellular carcinoma through ubiquitination and stabilization of HSP90AA1.Cell Commun Sign,2020,18(1):100. [18] Morales J,Li L,Fattah F J,et al.Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases.Crit Rev Eukary Gene Express,2014,24(1):15-28. [19] Wang C,Tang H,Geng A,et al.Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.Proc Nat Acad Sci USA,2020,117(42):26356-26365. [20] Tsai C H,Chen Y J,Yu C J,et al.SMYD3-mediated H2A.Z.1 methylation promotes cell cycle and cancer proliferation.Cancer Res,2016,76(20):6043-6053. |