急性重症酒精性肝炎肝动脉缓冲效应研究进展*

doi:10.3969/j.issn.1672-5069.2022.05.037

实用肝脏病杂志 ›› 2022, Vol. 25 ›› Issue (5): 753-756.doi: 10.3969/j.issn.1672-5069.2022.05.037

急性重症酒精性肝炎肝动脉缓冲效应研究进展^*

高志国综述, 王炳元审校

028000 内蒙古自治区通辽市传染病医院肝病中心(高志国);中国医科大学附属第一医院消化内科(王炳元)

收稿日期:2021-08-27 出版日期:2022-09-10 发布日期:2022-09-22
通讯作者: 王炳元,E-mail:Wangby0908＠163.com
作者简介:高志国,男, 44岁,副主任医师
基金资助:
国家青年自然科学基金资助项目(编号:8170030364)

Hepatic artery buffering response in patients with severe acute alcoholic hepatitis

Gao Zhiguo, Wang Bingyuan

Department of Alcohol-Related Liver Diseases, Infectious Disease Hospital, Tongliao 028000,Inner Mongolia Autonomous Region, China

Received:2021-08-27 Online:2022-09-10 Published:2022-09-22

摘要/Abstract

摘要： 目的急性重症酒精性肝炎患者肝窦存在致密胶原沉积,阻力增加阻碍了血液流经肝窦,窦性压力增加,门静脉血流不畅,门静脉向肝窦的灌注显著减少,此时就启动了肝动脉缓冲效应,后者可以抵消肝脏灌注的两个主要血管肝动脉或门静脉中任何一个的流量减少,维持肝脏总血流量在一个生理范围内,使肝脏灌注(肝动脉和门静脉血流之和)恢复正常。双功能多普勒超声可以无创评估肝脏血流动力学和定量肝动脉缓冲效应。因此,肝动脉缓冲效应可能成为诊断急性重症酒精性肝炎的重要检测方法之一。

关键词: 急性重症酒精性肝炎, 肝动脉缓冲效应, 双功能多普勒超声

Abstract: Objective There is a dense collagen deposition in hepatic sinusoide in patients with severe acute alcoholic hepatitis (SAAH), which increase the sinusoidal resistance with increased pressure and block blood flow through hepatic sinusoids. The portal vein blood flow is compromised in a retrograde manner with obviously reduced portal venous perfusion. Consequently, the hepatic artery buffering response (HABR) is triggered to counteract the decreased blood flow from hepatic artery or portal vein to maintain a physiological requirement and restore the hepatic perfusion, e.g., the sum of hepatic artery and portal vein blood flow. The hepatic hemodynamics and quantitative HABR can be assessed by Duplex Doppler ultrasonography, and the latter could be a noninvasive approach for the diagnosis of SAAH.

Key words: Severe acute alcoholic hepatitis, Hepatic artery buffering response, Duplex Doppler ultrasonography

高志国, 王炳元. 急性重症酒精性肝炎肝动脉缓冲效应研究进展^*[J]. 实用肝脏病杂志, 2022, 25(5): 753-756.

Gao Zhiguo, Wang Bingyuan. Hepatic artery buffering response in patients with severe acute alcoholic hepatitis[J]. Journal of Practical Hepatology, 2022, 25(5): 753-756.

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急性重症酒精性肝炎肝动脉缓冲效应研究进展^*

Hepatic artery buffering response in patients with severe acute alcoholic hepatitis

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