肝细胞癌患者肝内病灶超声造影参数变化*

doi:10.3969/j.issn.1672-5069.2022.01.023

摘要/Abstract

摘要： 目的探讨超声造影参数诊断肝细胞癌的应用价值。方法 2018年1月～2021年5月我院收治的HCC患者50例和乙型肝炎肝硬化患者50例,经肝穿组织病理学检查诊断,使用超声造影检查,获得病灶峰值强度(PI)、达峰时间(TTP)、渡越时间(MTT)和上升时间(RT)等参数,记录动脉期、静脉期和延迟期局部血容量和局部血流量。结果 HCC组动脉期局部血容量和局部血流量分别为(3399.7±783.7)rBV和(64.1±18.7)rBF,显著高于肝硬化组【分别为(1363.8±773.5)rBV和(41.9±10.6)rBF,P<0.05】;静脉期和延迟期局部血容量分别为(1325.8±546.3)rBV和(463.2±143.2)rBF,显著低于肝硬化组【分别为(1775.4±541.3)rBV和(721.2±242.5)rBF,P<0.05】;HCC组病灶RT、TTP和mTT分别为(15.7±8.3)s、(22.6±5.4)s 和(133.5±92.3)s,显著低于肝硬化组【分别为(26.3±6.4)s、(32.3±7.6)s和(160.4±112.8)s,P<0.05】,而PI为(85.2±48.2)dB,显著大于肝硬化组【(31.5±3.5)dB,P<0.05】;以病理学检查诊断为金标准,超声造影定量分析检测诊断的灵敏度为92.0%,特异度为92.0%,准确度为80.0%。结论应用超声造影定量参数诊断HCC病灶具有很高的临床价值。

关键词: 肝细胞癌, 超声造影参数, 诊断

Abstract: Objective The aim of this study was to explore the application of contrast-enhanced ultrasound (CEUS) parameters in the quantitative diagnosis of patients with hepatocellular carcinoma (HCC). Methods 50 patients with HCC and 5o patients with liver cirrhosis were admitted to our hospital between January 2018 and May 2021, and the diagnoses in all patients were confirmed by pathological examination after liver biopsies. The CEUS was conducted to obtain the peak intensity (PI), the time to peak (TTP), mean trasit time (mTT), the rise time (RT), and the blood perfusion feature was recorded. Results The local blood volume and local blood flow during arterial phase in patients with HCC were (3399.7±783.7) rBV and (64.1±18.7) rBF, significantly higher than [(1363.8±773.5) rBV and (41.9±10.6) rBF, respectively, P<0.05] in patients with cirrhosis, and the local blood volume during venous and delayed phases were (1325.8±546.3) rBV and (463.2±143.2) rBF, significantly lower than [(1775.4±541.3) rBV and (721.2±242.5) rBF, P<0.05] in patients with cirrhosis; the RT, TTP and mTT in cancerous foci were (15.7±8.3) s, (22.6±5.4) s and (133.5±92.3)s, significantly lower than [(26.3±6.4)s, (32.3±7.6)s and (160.4±112.8)s, respectively, P<0.05], while the PI was (85.2±48.2)dB, significantly higher than [(31.5±3.5)dB, P<0.05] in patients with cirrhosis; at the base of histopathological diagnosis as the gold criteria, the sensitivity, specificity and accuracy by CEUS diagnosis were 92.0%, 92.0% and 80.0%. Conclusion The CEUS quantitative parameters could help the diagnosis of patients with HCC, which is of great clinical application.

Key words: Hepatocellular carcinoma, Contrast-enhanced ultrasound parameter, Diagnosis

肖倩, 周展, 胡小丽. 肝细胞癌患者肝内病灶超声造影参数变化^*[J]. 实用肝脏病杂志, 2022, 25(1): 92-95.

Xiao Qian, Zhou Zhan, Hu Xiaoli. Clinical application of contrast-enhanced ultrasound parameters in the quantitative diagnosis of patients with hepatocellular carcinoma[J]. Journal of Practical Hepatology, 2022, 25(1): 92-95.

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肝细胞癌患者肝内病灶超声造影参数变化^*

Clinical application of contrast-enhanced ultrasound parameters in the quantitative diagnosis of patients with hepatocellular carcinoma

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