超声引导下经皮穿刺置管引流联合聚桂醇泡沫硬化治疗单纯性肝囊肿患者疗效研究*

doi:10.3969/j.issn.1672-5069.2020.06.038

摘要/Abstract

摘要： 目的观察在超声引导下经皮穿刺置管引流联合聚桂醇泡沫硬化治疗单纯性肝囊肿(SHC)患者的疗效。方法将112例SHC患者随机分为观察组56例和对照组56例,采用超声引导下经皮穿刺置管引流,分别注射聚桂醇泡沫硬化或聚桂醇硬化治疗。采用化学发光法检测血清C反应蛋白(CRP)水平,采用磁微粒化学发光法检测血清皮质醇(Cor)水平。结果在术后半年随访,观察组总有效率为100.0%,与对照组的92.9%比,无统计学差异(P＞0.05);观察组不良反应发生率为5.4%,显著低于对照组的19.6%(P<0.05);术后1 w,两组血清总胆红素、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、碱性磷酸酶、胆碱酯酶、C反应蛋白、皮质醇和血糖水平变化无显著性差异(P>0.05)。结论在超声引导下经皮穿刺置管引流联合聚桂醇注射硬化治疗单纯性肝囊肿患者疗效肯定,采取聚桂醇泡沫注射可能能减少并发症的发生。

关键词: 单纯性肝囊肿, 超声引导, 经皮穿刺置管引流, 聚桂醇, 治疗

Abstract: Objective The aim of this study was to investigate the efficacy of ultrasound-guided percutaneous catheter aspiration and sclerotherapy with polygui alcohol foam in the treatment of patients with simple hepatic cyst (SHC). Methods 112 patients with SHC were randomly divided into observation group (n=56) and control group (n=56), and the patients in the observation group were treated with ultrasound-guided percutaneous catheter drainage with polygui alcohol foam sclerosis and those in the control group were treated with ultrasound-guided percutaneous catheter drainage with 1% lauromacrogol sclerotherapy. All patients were followed-up for six months. Serum C-reactive protein (CRP) level was detected by chemiluminescence method, serum cortisol (Cor) level was detected by magnetic particle chemiluminescence method, and blood glucose (GLU) level was detected by hexokinase method. Results Six months after operation, the total effective rate in the observation group was 100.0%, which was not statistically different compared to 92.9% in the control group (P>0.05); the incidence of adverse reactions in the observation group was 5.4%, which was significantly lower than 19.6% (P<0.05) in the control group; 1 week after treatment, serum bilirubin, alanine aminotransferase, aspartate aminotransferase, ALP, CHE, CRP, cortisol and blood glucose levels in the two groups were not significantly different (P>0.05). Conclusion Ultrasound-guided percutaneous puncture with catheter drainage and polygui alcohol foam sclerosis in treatment of patients with simple hepatic cysts is efficacious, which might decrease the side effects and is a safe procedure, warranting further clinical application.

Key words: Simple hepatic cyst, Ultrasound-guidance, Percutaneous puncture and catheter drainage, Polygui alcohol foam sclerosis, Treatment

王琳玲, 周琼, 王月爱. 超声引导下经皮穿刺置管引流联合聚桂醇泡沫硬化治疗单纯性肝囊肿患者疗效研究^*[J]. 实用肝脏病杂志, 2020, 23(6): 909-912.

Wang Linling, Zhou Qiong, Wang Yueai. Ultrasound-guided percutaneous catheter drainage with polygui alcohol foam sclerosis intreatment of patients with simple hepatic cyst[J]. Journal of Practical Hepatology, 2020, 23(6): 909-912.

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超声引导下经皮穿刺置管引流联合聚桂醇泡沫硬化治疗单纯性肝囊肿患者疗效研究^*

Ultrasound-guided percutaneous catheter drainage with polygui alcohol foam sclerosis intreatment of patients with simple hepatic cyst

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