应用18F-FDG PET/CT检查评价肝泡型包虫病肝内病灶活性研究*

doi:10.3969/j.issn.1672-5069.2020.01.030

实用肝脏病杂志 ›› 2020, Vol. 23 ›› Issue (1): 110-113.doi: 10.3969/j.issn.1672-5069.2020.01.030

应用¹⁸F-FDG PET/CT检查评价肝泡型包虫病肝内病灶活性研究^*

韩为清, 崔佳宾, 杨予川

810000 西宁市青海省第五人民医院影像科(韩为清); 黑龙江省鸡西鸡矿医院影像科(崔佳宾); 哈尔滨医科大学附属第一医院放射科(杨予川)

收稿日期:2019-04-01 发布日期:2020-01-14
作者简介:韩为清,男,大学本科,副主任医师。E-mail:284688951@qq.com
基金资助:
青海省自然科学基金资助项目(编号：2013-Z-918)

Evaluation of intrahepatic lesion activity by¹⁸F-FDG PET/CT scan in patients with hepatic alveolar echinococcosis

Han Weiqing , Cui Jiabin, Yang Yuchuan

Department of Radiology,Fifth People’s Hospital,Xining 810000,Qinghai Province,China

Received:2019-04-01 Published:2020-01-14

摘要/Abstract

摘要： 目的观察¹⁸-氟脱氧葡萄糖(¹⁸F-FDG)PET/CT检查对肝泡型包虫病(HAE)患者治疗前后肝内病灶活性的评价作用。方法 2016年6月～2018年6月我院收治的109例HAE患者,按体质量服用阿苯达唑脂质剂10 mg·d^-1·kg^-1,治疗6个月。所有患者均于治疗前后行¹⁸F-FDG PET/CT检查,分析病灶边缘带最大标准放射性摄取值(SUV_max)。结果在109例患者中,治疗前PET/CT检查显示HAE病灶多呈混杂密度占位灶,形状不规则,内见钙化灶、液化性坏死区,边界不清晰,多呈侵袭性生长,病灶边缘带见放射性药物分布影,且高于肝脏,病灶内部未见明显放射性分布;在阿苯达唑脂质剂治疗后6个月,PET/CT检查显示75例病灶周边放射性浓聚现象消失或明显降低,34例病灶边缘带放射性分布较治疗前轻度变淡;109例患者在阿苯达唑治疗后病灶边缘增殖浸润带SUV_max值为(3.6±1.4),显著低于治疗前【(4.9±1.9),P＜0.05】。结论应用¹⁸F-FDG PET/CT检查能够帮助评估HAE病灶活性,从而指导药物治疗。

关键词: 肝泡型包虫病, PET/CT检查, ¹⁸-氟脱氧葡萄糖, 病灶活性

Abstract: Objective The aim of this study was to investigate the evaluation of intrahepatic lesion activity by ¹⁸F-FDG PET/CT scan in patients with hepatic alveolar echinococcosis (HAE). Methods 109 patients with HAE admitted to our hospital between June 2016 and June 2018, and all patients received albendazoletreatment for six months. All patients underwent ¹⁸F-FDG PET/CT scan before and after treatment. Results PET/CT examination in 109 patients with HAEbefore treatment showed that most HAE lesions were with mixeddensity and irregular shape, with calcification,liquefaction necrosis, unclear boundary and aggressive growth. The radioactive distribution was found in the edge of the lesions, which was higher than that of the liver; PET/CT scan at six month after the treatment showed that the radiation activity around the lesions disappeared or significantly decreased in 75 cases, and the radiation distribution was slightly reduced in 34 cases; the maximum standardized uptake value of the radiation distribution in the proliferative infiltration zone in the 109 patients after the albendazole treatment was(3.6±1.4), significantly lower than 【(4.9±1.9), P＜0.05】 before treatment. Conclusion The use of ¹⁸F-FDG PET/CT scan might help evaluate the lesion activity,which could guide the albendazole treatment.

Key words: Hepatic alveolar echinococcosis, ¹⁸F-FDG, PET/CT scan, Lesion activity

韩为清, 崔佳宾, 杨予川. 应用¹⁸F-FDG PET/CT检查评价肝泡型包虫病肝内病灶活性研究^*[J]. 实用肝脏病杂志, 2020, 23(1): 110-113.

Han Weiqing , Cui Jiabin, Yang Yuchuan. Evaluation of intrahepatic lesion activity by¹⁸F-FDG PET/CT scan in patients with hepatic alveolar echinococcosis[J]. Journal of Practical Hepatology, 2020, 23(1): 110-113.

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应用¹⁸F-FDG PET/CT检查评价肝泡型包虫病肝内病灶活性研究^*

Evaluation of intrahepatic lesion activity by¹⁸F-FDG PET/CT scan in patients with hepatic alveolar echinococcosis

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