胰高血糖素样肽-1改善非酒精性脂肪性肝病作用机制研究进展*

doi:10.3969/j.issn.1672-5069.2018.02.047

摘要/Abstract

摘要： 近期研究表明,胰高血糖素样肽-1受体激动剂可从改善肝细胞脂质代谢、抑制炎症反应、调节细胞自噬等多个环节减轻非酒精性脂肪性肝病（NAFLD）患者肝脏脂质沉积,改善组织学损伤,有望成为治疗NAFLD药物的新选择。

Abstract: Glucagon-like peptide-1 receptor agonists could meliorate hepatic lipid deposition and histological damage by regulating lipid metabolism,inflammation and autophagy in pathogenesis of non-alcoholic fatty liver disease （NAFLD）,which may serve as a new option for treatment of patients with NAFLD.

Key words: Non-alcoholic fatty liver disease, Glucagon-like peptide 1, Pathogenesis

信丰智综述, 曹海霞, 范建高审校. 胰高血糖素样肽-1改善非酒精性脂肪性肝病作用机制研究进展*[J]. 实用肝脏病杂志, 2018, 21(2): 313-316.

Xin Fengzhi, Cao Haixia, Fan Jiangao. Glucagon-like peptide-1 in melioration of non-alcoholic fatty liver disease[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2018, 21(2): 313-316.

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