关键词: 非酒精性脂肪性肝病, 代谢综合征, 内皮功能, 危险因素

Abstract: Objective To compare the differences of vascular endothelial functions between patients with nonalcoholic fatty liver disease（NAFLD） and metabolic syndrome（MS） and with NAFLD without MS,and to analyze the related risk factors. Methods Clinical data of the hospitalized patients with NAFLD between January 2015 and October 2015 in the First Affiliated Hospital of Xinjiang Medical University were collected. 91 patients were divided into group A（NAFLD without MS） and group B （NAFLD with MS）. Reactive hyperemia index （RHI） in fingers was measured by Endo-PAT2000. A binary logistic regression analysis was performed to define the risk factors for the endothelial dysfunction in patients with NAFLD. Results The levels of RHI in group A （n=52） were lower than in group B （n=39）（1.63±0.29 vs. 1.81±0.29,P<0.01）;The levels of waistline,BMI,systolic blood pressure,fasting plasma glucose and triglycerides in group A[（92.75±9.10） cm,（25.99±2.98） kg/m², （117.87±15.08） mmHg,（5.08±0.89） mmol/L and（1.46±0.65） mmol/L] were much lower than those [（101.64±10.86） cm,（28.07±3.97） kg/m²,（127.41±12.03） mmHg,（6.87±2.90） mmol/L and （2.69±2.22） mmol/L] in group B （P<0.05）;But the levels of high density lipoprotein cholesterol,aspartate aminotransferase and alanine aminotransferase in group A[（1.26±0.34） mmol/L,（62.48±9.79） U/L and （93.04±19.56） U/L] were higher than those [（0.93±0.30） mmol/L,（37.70±10.45） U/L and（55.39±15.59） U/L] in group B（P<0.05）;Fasting plasma glucose,free fatty acid and alanine aminotransferase were the risk factors for endothelial dysfunction in patients with NAFLD （OR=1.34,OR=5.58,OR=1.04）. Conclusion The RHI in patients with NAFLD is lower than in patients with NAFLD and MS. Several risk factors for the endothelial dysfunction in patients with NAFLD are associated with glucose and lipid metabolic disorders and liver inflammation.

Key words: Nonalcoholic fatty liver disease, Metabolism syndrome, Endothelial function, Risk factor