一种新型超声显影导管声学特性研究*

doi:10.3969/j.issn.1672-5069.2024.04.005

实用肝脏病杂志 ›› 2024, Vol. 27 ›› Issue (4): 511-514.doi: 10.3969/j.issn.1672-5069.2024.04.005

一种新型超声显影导管声学特性研究^*

冯谦, 王睿, 陈重

610083 成都市解放军西部战区总医院超声诊断科

收稿日期:2023-12-05 出版日期:2024-07-10 发布日期:2024-07-10
通讯作者: 陈重,E-mail:ultrasoundcz@163.com
作者简介:冯谦,女,36岁,大学本科,主治医师。研究方向:超声介入诊断与治疗。E-mail:185954824@qq.com
基金资助:
^*全军计划生育专项课题(编号:23JSZ20)

Acoustic performance of a newly knitted catheter with an improved ultrasonography visibility

Feng Qian, Wang Rui, Chen Zhong

Department of Ultrasound, General Hospital, Western Theater Command of PLA, Chengdu 610083, Sichuan Province, China

Received:2023-12-05 Online:2024-07-10 Published:2024-07-10

摘要/Abstract

摘要： 目的探讨应用磁共振质子密度脂肪分数(MRI-PDFF)诊断超重和肥胖儿童非酒精性脂肪性肝炎(NASH)的效能。方法 2022年12月～2023年12月江油市903医院诊治的超重/肥胖的非酒精性脂肪性肝病(NAFLD)儿童102例,其中超重儿童74例和肥胖儿童28例,使用3.0 T MRI扫描仪行肝脏检查,获取MRI-PDFF,使用FibroScan 诊断仪检查获得肝脏硬度检测(LSM)和受控衰减参数(CAP),行肝穿刺诊断NASH,绘制受试者工作特征曲线(ROC),计算曲线下面积(AUC),评估诊断效能。结果在102例超重/肥胖的NAFLD儿童中,经组织学检查诊断单纯性非酒精性脂肪肝(SNFL)75例和NASH 27例;NASH组BMI、血清ALT、AST、TG、MRI-PDFF、LSM和CAP分别为(32.2±3.4)kg/m²、(92.7±31.3)U/L、(96.8±34.1)U/L、(3.1±1.2)mmol/L、(12.5±4.7)%、(11.7±1.4)kPa和(370.4±146.9)dB/m,与SNFL组【分别为(26.7±2.2)kg/m²、(38.2±4.4)U/L、(33.0±3.4)U/L、(2.3±0.7)mmol/L、(7.7±2.0)%、(6.2±1.0)kPa和(262.3±61.2)dB/m】比,差异具有统计学意义(P<0.05),NASH组超重和肥胖占比分别37.0%和63.0%,与SNFL组的85.3%和14.7%比,差异具有统计学意义(P<0.05); 经ROC曲线分析显示,以MRI-PDFF为11.9%为截断点,其诊断NASH的AUC为0.87(95%CI为0.80～0.93),敏感性为81.5%,特异性为85.3%,而分别以LSM为10.8 kPa和CAP为310.5dB/m为截断点,其诊断的AUC为0.81(95%CI为0.78～0.89),敏感性为85.2%,特异性为58.7%,后者的特异性较差。结论应用MRI-PDFF诊断儿童NASH的效能较优,但考虑到临床的便捷性,使用弹性成像检测诊断也可获得初步结果,以便必要时进一步检查。

关键词: 超声显影, 超声介入, 编织导管, 声学, 体内

Abstract: Objective This study was conducted to investigate ultrasonography visibility of a newly knitted catheter. Methods Tube wall structure, reflected acoustic signal intensity and ultrasonography visibility in liquid and living animal liver tissue between conventional plastic catheter (n=10) and newly knitted catheter (n=10) were compared by through electron microscopy, hydrophone acoustic signal detection, flume catheter ring experiment and live pig liver implantation. Results Under electron microscope, interlaced polymer fibers were observed in the wall of the newly knitted tube, whose acoustic impedance values were different from those of the tube body, and microbubbles were also observed around the intersections of fibers; hydrophone detection experiments showed that the fundamental and second harmonic signals received by the newly knitted catheter were more evenly distributed and less angle dependent; in the catheter ring experiment, complete display rate was (91.9±1.2)%, echo loss rate was(4.0±0.7)%) and multiple reflection artifact display rate was(4.3±0.9)%, all much superior to conventional plastic catheter (P<0.01); in live pig liver in vivo, the echo intensity, wall continuity and tip development of the newly knitted catheter were much better than those of conventional plastic catheter. Conclusion The newly knitted catheter has stronger ultrasound visibility, which might be validated in clinical application.

Key words: Ultrasound visibility, Ultrasound intervention, Knitted catheter, Acoustic performance, In vivo

冯谦, 王睿, 陈重. 一种新型超声显影导管声学特性研究^*[J]. 实用肝脏病杂志, 2024, 27(4): 511-514.

Feng Qian, Wang Rui, Chen Zhong. Acoustic performance of a newly knitted catheter with an improved ultrasonography visibility[J]. Journal of Practical Hepatology, 2024, 27(4): 511-514.

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一种新型超声显影导管声学特性研究^*

Acoustic performance of a newly knitted catheter with an improved ultrasonography visibility

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