空气污染物PM2.5与非酒精性脂肪性肝病发病研究进展

doi:10.3969/j.issn.1672-5069.2021.02.038

摘要/Abstract

摘要： 目的非酒精性脂肪性肝病(NAFLD)的发病以胰岛素抵抗(IR)和脂质代谢紊乱为基础,目前存在广泛接受的“多次打击学说”发病机制。现有研究报道,吸入空气颗粒物(PM)2.5会诱发肝细胞氧化应激和炎症反应,从而影响肝脏的脂代谢,引起肝细胞损伤。此外,PM2.5与IR、肥胖和脂肪合成信号通路之间也存在密切的关联,本综述将讨论这些问题,并分析PM2.5对NAFLD发生机制的潜在影响,为预防和治疗NAFLD患者提供新的视角。

关键词: 非酒精性脂肪性肝病, 胰岛素抵抗, 肥胖, 脂代谢, 空气颗粒物2.5

Abstract: Objective The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is related to insulin resistance (IR) and lipid metabolism disorders. Currently, the widely accepted hypothesis of NAFLD is the "multiple hits theory". Studies have reported that inhalation of ambient particular matter (PM) 2.5 could induce oxidative stress and inflammation in liver tissues, impacting liver lipid metabolism and causing liver cell damage. In addition, PM2.5 is also closely related to IR, obesity and fat synthesis signaling pathways. This review will summarize the relationship between IR, obesity, lipid metabolism and PM2.5, and analyze the potential impact of PM2.5 on the pathogenesis of NAFLD, which might have implications for the prevention and treatment of the entity.

Key words: Non-alcoholic fatty liver disease, Insulin resistance, Obesity, Lipid metabolism, Ambient particular matter 2.5

吴伟杰, 丁雯瑾, 范建高. 空气污染物PM2.5与非酒精性脂肪性肝病发病研究进展[J]. 实用肝脏病杂志, 2021, 24(2): 297-300.

Wu Weijie, Fan Jiangao. Is ambient particular matter 2.5 correlated to pathogenesis of nonalcoholic fatty liver disease?[J]. Journal of Practical Hepatology, 2021, 24(2): 297-300.

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