胆囊癌患者血清sVEGF-C和CEA水平变化及其与组织病理学特征的关系探讨*

doi:10.3969/j.issn.1672-5069.2020.02.034

实用肝脏病杂志 ›› 2020, Vol. 23 ›› Issue (2): 284-287.doi: 10.3969/j.issn.1672-5069.2020.02.034

胆囊癌患者血清sVEGF-C和CEA水平变化及其与组织病理学特征的关系探讨^*

李嘉, 蒋基令, 黄梦黎, 黄俊海, 陈怡媚

518021 深圳市中医院外一科(李嘉,黄梦黎,蒋基令);深圳市妇幼保健院乳腺科(陈怡媚);广州中医药大学第一附属医院肝胆外科(黄俊海)

收稿日期:2019-06-17 出版日期:2020-03-10 发布日期:2020-04-20
通讯作者: 蒋基令,E-mail:405836898@qq.com
作者简介:李嘉,男,39岁,医学硕士
基金资助:
深圳市卫生和计划生育委员会科研计划项目(编号:SZFZ2017100)

Correlation of serumvascular endothelial growth factor-C and carcinoembryonic antigen levels to prognosis in patients with gallbladder cancer

Li Jia, Jiang Jiling, Huang Mengli, et al

Department of General Surgery, Traditional Chinese Medicine Hospital, Shenzhen 518021, Guangdong Province, China

Received:2019-06-17 Online:2020-03-10 Published:2020-04-20

摘要/Abstract

摘要： 目的研究血清血管内皮生长因子-C(sVEGF-C)和癌胚抗原(CEA)水平与胆囊癌患者临床和病理学特征的关系。方法 2011年2月～2018年1月收治的93例胆囊癌患者,采用双抗体夹心酶联免疫吸附法检测血清sVEGF-C水平,采用放射免疫分析法检测血清CEA水平,分析血清sVEGF-C和CEA水平与胆囊癌患者临床和病理学特征的关系。结果不同肿瘤浸润程度(T分期)、肿瘤淋巴转移程度(N分期)、肿瘤远处转移(M分期)的胆囊癌患者血清sVEGF-C和CEA水平相差显著(P＜0.05);中位随访22个月,在93例患者中死亡48例(51.6%),生存45例(48.4%);死亡组血清sVEGF-C水平为(84.9±20.7)pg/mL,显著高于生存组[(56.4±18.9)pg/mL,P＜0.05],血清CEA水平为(138.7±49.6)μg/L,显著高于生存组[(76.8±27.4)μg/L,P＜0.05];多因素Logistic回归分析显示,临床病理分期(OR=6.658,95%CI=1.800～24.632)及血清sVEGF-C(OR=4.005,95%CI=1.292～12.415)和CEA(OR=3.170,95%CI=1.482～6.849)水平是影响胆囊癌患者预后的独立危险因素(P＜0.05)。结论胆囊癌患者血清sVEGF-C和CEA水平显著升高,可能与不良预后相关,值得积极的深入研究。

关键词: 胆囊癌, 血管内皮生长因子-C, 癌胚抗原, 预

Abstract: Objective The purpose of this study was to investigate the correlation of serumvascular endothelial growth factor-C (sVEGF-C) and carcinoembryonic antigen(CEA) levels to prognosis in patients with gallbladder cancer. Methods 93 patients with gallbladder cancer were included in this study between February 2011 and January 2018, and serum sVEGF-C levels were detected by double antibody-sandwich enzyme-linked immunosorbent assay, and serum CEA levels were detected by radioimmunoassay. The correlation of serum sVEGF-C and CEA levels to the prognosis of patients with gallbladder cancer was analyzed. Results Serum sVEGF-C and CEA levels were significantly different in gallbladder cancer patients with different tumor infiltration (Tstage), lymphatic metastasis (N stage), distant metastasis (M stage) and clinopathological stage (P<0.05); during 22 month follow-up period, 45 survived (48.4%) and 48 died (51.6%); serum sVEGF-C level in the dead group was (84.9±20.7) pg/mL, significantly higher than [(56.4±18.9) pg/mL,P<0.05], and serum CEA level was (138.7±49.6) μg/L, significantly higher than [(76.8±27.4) μg/L,P<0.05] in the survival group; multivariate Logistic regression analysis showed that clinopathological stage (OR=6.658, 95% CI=1.800-24.632), serum sVEGF-C (OR=4.005,95% CI=1.292-12.415) and CEA (OR=3.170, 95% CI=1.482-6.849) were the independent risk factors affecting the prognosis of patients with gallbladder cancer (P<0.05). Conclusion Serum sVEGF-C and CEA levels increase greatly in patients with gallbladder cancer, which might impact the poor prognosis and warrants further investigation.

Key words: Gallbladder cancer, Vascular endothelial growth factor-C, Carcinoembryonic antigen, Prognosis

李嘉, 蒋基令, 黄梦黎, 黄俊海, 陈怡媚. 胆囊癌患者血清sVEGF-C和CEA水平变化及其与组织病理学特征的关系探讨^*[J]. 实用肝脏病杂志, 2020, 23(2): 284-287.

Li Jia, Jiang Jiling, Huang Mengli, et al. Correlation of serumvascular endothelial growth factor-C and carcinoembryonic antigen levels to prognosis in patients with gallbladder cancer[J]. Journal of Practical Hepatology, 2020, 23(2): 284-287.

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胆囊癌患者血清sVEGF-C和CEA水平变化及其与组织病理学特征的关系探讨^*

Correlation of serumvascular endothelial growth factor-C and carcinoembryonic antigen levels to prognosis in patients with gallbladder cancer

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