关键词: 肝转移癌, 结直肠癌, 微波消融术, 经肝动脉栓塞化疗, 临床疗效

Abstract: Objective To investigate the efficacy of microwave ablation combined with transcatheter arterial chemoembolization（TACE） in treatment of patients with hepatic metastasis from colorectal cancer. Methods 90 patients with liver metastasis who had colorectal cancer removed were recruited in our hospital between June 2012 and June 2015,and were divided into control group receiving systemic chemotherapy （n=45） and observation group receiving microwave ablation combined with TACE （n=45）. Comparison of the therapeutic efficacy,prognosis and changes of peripheral blood lymphocyte subsets between the two groups was made. Results At the end of 6 month followed-up,the complete response,partial response,stable disease and progress of disease in the combination group were 28.9%,40.0%,20.0% and 11.1%,significantly superior to 11.1%,28.9%,26.7% and 33.3% （x²=7.571,P=0.006） in the control group;at presentation,the percentages of peripheral blood CD8⁺ cells,CD4⁺ cells and CD3⁺ cells as well as the ratio of CD4⁺/CD8⁺ cells in two groups were not significantly different（P>0.05）,while at the end of three month treatment,the percentages of peripheral blood CD8⁺ cells,CD4⁺ cells and CD3⁺ cells as well as the ratio of CD4⁺/CD8⁺ cells in the combination group improved obviously as compared to those in the control（t=7.256,t=5.916,t=7.701,t=7.013,P<0.01）;the follow-up demonstrated that the survival time in the control group was （16.0±5.2） m,significantly shorter than （29.1±8.4） m（t=8.895,P<0.001） in the combination group. Conclusion The application of microwave ablation and interventional embolization chemotherapy in the treatment of patients with liver metastasis from colorectal cancer has to some intent clinical good efficacy,which might effectively improve the immune function of patients and prolong the patient's survival.

Key words: Colorectal liver metastases, Microwave ablation, Transcatheter arterial chemoembolization, Clinical efficacy