慢性乙型肝炎患者PD-1/PD-L1信号通路的免疫调节作用研究进展

doi:10.3969/j.issn.1672-5069.2015.06.032

摘要/Abstract

摘要： 程序性死亡分子-1（PD-1）是T淋巴细胞膜表面表达的负向协同刺激分子, 与其主要配体（PD-L1）形成通路后,可以减弱T淋巴细胞的免疫反应,甚至导致T淋巴细胞功能衰竭。PD-1/PD-L1信号通路在乙型肝炎病毒感染后的效应T细胞免疫耐受中具有重要作用,阻断该途径可能是抗病毒治疗的方向之一,具有良好的应用前景。

关键词: 慢性乙型肝炎, 程序性死亡分子-1/程序性死亡分子-1配体, T淋巴细胞, 免疫调节

Abstract: Programmed cell death-1（PD-1）,as an inhibitory co-stimulatory molecule,is expressed on the surface of T lymphocyte membranes. After interacting with its main ligand,programmed death-1 ligand（PD-L1）,PD-1 decreases immune response of T lymphocytes,and even damages the overall functioning of T lymphocytes. PD-1/PD-L1 signaling pathway plays an important role in the tolerance of T cell immune response triggered by hepatitis B virus infection. Studies indicate that blocking this pathway may provide an new insights into antiretroviral therapy,and might be a promising applications in clinical practice.

Key words: Chronic Hepatitis B, PD-1/PD-L1, T lymphocytes, Immunomodulation

曹霖霖综述，张国梁审校. 慢性乙型肝炎患者PD-1/PD-L1信号通路的免疫调节作用研究进展[J]. 实用肝脏病杂志, 2015, 18(6): 682-686.

Cao Linlin， Zhang Guoliang.. Immunoregulatory effect of PD-1/PD-L1 signaling pathway in chronic hepatitis B viral infection[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2015, 18(6): 682-686.

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