单光子发射型计算机断层显像在肝脏储备功能评估中的应用

doi:10.3969/j.issn.1672-5069.2011.01.032

实用肝脏病杂志 ›› 2011, Vol. 14 ›› Issue (1): 74-76.doi: 10.3969/j.issn.1672-5069.2011.01.032

单光子发射型计算机断层显像在肝脏储备功能评估中的应用

孙永刚,李建生,荚卫东,许戈良,马金良,葛勇胜,余继海

230001 安徽医科大学附属省立医院肝脏外科/肝癌研究中心

收稿日期:2010-09-29 出版日期:2011-02-10 发布日期:2016-04-15
通讯作者: 李建生，E-mail：lijiansheng1953@163.com
作者简介:孙永刚男，31岁，硕士研究生。主要从事肝脏外科学研究。

Received:2010-09-29 Online:2011-02-10 Published:2016-04-15

摘要/Abstract

摘要： 单光子发射型计算机断层显像（SPECT）动态检查肝脏储备功能，具有方便、可靠、直观、抗干扰能力强等优点，越来越受到肝脏外科界的重视。从单纯的判断肝脏损伤程度，预测肝脏术后的可能并发症，肝脏储备功能的评估，到模拟切除判断术后肝脏功能等，均表现出其广阔的发展前景。本文重点讨论其在肝脏储备功能评估中的作用。

关键词: 单光子发射型计算机断层显像, 清除率, 受体指数, 心肝相关指数

孙永刚,李建生,荚卫东,许戈良,马金良,葛勇胜,余继海. 单光子发射型计算机断层显像在肝脏储备功能评估中的应用[J]. 实用肝脏病杂志, 2011, 14(1): 74-76.

[1] LIN TY，LEE CS，CHEN CC，et al. Regeneration of human liver after hepatic lobectomy studied by repeated liver scanning and repeated needle biopsy[J]. Ann Surg，1979，190（1）:48-53.
[2] 吴孟超，温增庆，徐峰，等. 肝癌肝切除术后并发症的处理（附592 例报告）[J]. 中华肝胆外科杂志，2002，8：435-436.
[3] MORELL AG，IRVINE RA，STEMLIEB I，et al. Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo[J]. J Biol Chem，1968，243（1）:155-159.
[4] 李文新，张荣军，谭成，等. 肝细胞表面去唾液酸糖蛋白受体的流式细胞分析[J]. 生物化学与生物物理进展，2000，27：397-394.
[5] CASEY CA，MCVICKER BL，DONOHUE TM JR，et al. Liver asialo-glycoprotein receptor levels correlate with severity of alcoholic liver damage in rats[J]. J Appl Physiol，2004，96:76-80.
[6] LI XF，TAKI J，KINUYA S，et al. Asialoglycoprotein receptoconcentration in tumor-bearing livers and its fate early aftetheir sectorial resectuon[J]. Ann Nucl Med，2003，17（6）:489-493.
[7] ARLENE K，VAN VLIET. 99mTc-GSA scintigraphy with SPECT for assessment of hepatic function and functional volume during liver regeneration in a rat model of partial hepatectomy[J]. J Nucl Med，2008，49（1）:122-128.
[8] VAN DEN ESSCHERT JW，DE GRAAF W. Volumetric and functional recovery of the remnant liver after major liver resection with prior portal vein embolization:recovery after PVE and liver resection[J]. Gastrointest Surg，2009，13(8):1464-1469.
[9] MITSUMORI A，NAGAYA I，KIMOTO S，et al. Preoperative evaluation of hepatic functional reserve following hepatectomy by technetium-99m galactosyl human serum albumin liver scintigraphy and computed tomography[J]. Eur J Nucl Med，1998，25:1377-1382.
[10] NANASHIMA A，YAMAGUCHI H，SHIBASAKI S，et al. Relationship between CT volumetry and functional liver volume using technetium-99m galactosyl serum albumin scintigraphy in patients undergoing preoperative portal vein embolization before major hepatectomy:a preliminary study[J]. Dig Dis Sci，2006，51:1190-1195.
[11] SHIOMI S，SASAKI N，TAMORI A，et al. Use of scintigraphy with 99mtechnetium galactosyl human serumalbumin for staging of primary biliary cirrhosis and assessment prognosis[J]. J Gastroenterol Hepatol，1999，14:566-571.
[12] SASAKI N，SHIOMI S，IWATA Y，et al. Clinical usefulness of scintigraphy with 99mTc-galactosyl human serum albumi for prognosis of cirrhosis of the liver[J]. J Nucl Med，1999，40（10）:1625-1626.
[13] 毛一雷，董一女，张现忠，等. 99mTc-DTPA-半乳糖人血白蛋白在不同小鼠肝损伤模型中肝功能现象的应用[J]. 中国医学学院报，2008，04（9）：404-408.
[14] NANASHIMA A，YAMAGUCHI H，SHIBASAKI S，et al. Relationship between indocyanine green test and technetium-99m-galactosyl serum albumin scintigraphy in patients scheduled for hepatectomy:Clinical evaluation and patient outcome Nanashima[J]. Hepatol Res，2004，28:184-190.
[15] KAWAMURA H，KAMIYAMA T，NAKAGWA T，et al. Preoperative evaluation of hepatic functional reserve by converted ICGR15 calculated from 99mTc-GSA scintigraphy[J]. J Gastroenterol Hepatol，2008，23（8）:1235-1241.
[16] 杨日高，顾晓东，李大江，等. 应用ASGPR相关指标结合ICG15建立肝脏储备功能定量评估体系[J]. 中华肝胆外科杂志，2006，12（1）：43-46.
[17] SHIMIZU Y，AOKI T，KUSANO T，et al. Natural course of the remnant hepatic functional reserve as estimated by technetium-99m-galactosyl human serum albumin scintigraphy after a hepatectomy[J]. Gastroenterology，2010，45（3）: 308-316.
[18] OSADA H，HONDA N，TAKAHSHI T，et al. Relationship between（99m）Tc-GSA scintigraphic indices of liver function reserve and portal circulation in patients with chronic liver disease[J]. Ann Nucl Med，2007，21（5）:245-249.
[19] KIRA T，TOMIGUCHI S，KIRA M，et al. Quantitative evaluation of the hepatic functional reserve using technetium-99m DTPA-galactosyl human serum albumin before and after transjugular intrahepatic portosystemic shunt[J]. Eur J Nucl Med，1997，24:1268-1272.
[20] KAIBORI M，HA-KAWA SK，UCHIDA Y，et al. Liver regeneration in donors evaluated by Tc-99m-GSAscintigraphy after living donor liver transplantation[J]. Dig Dis Sci， 2008，53:850-855.
[21] SELZNER M，CLAVIEN PA. Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway[J]. Hepatology，2000，31（1）:35-42.
[22] DE GRAAF W，VETELAINEN RL，DE BRUIN K，et al. 99mTc-GSA scintigraphy with SPECT for assessment of hepatic function and functional volume during liver regeneration in a rat model of partial hepatectomy[J]. J Nucl Med，2007，12（10）:122-128.
[23] NISHI H，TAKAHASHI T，MATSUMIYA G，et al. Preoperative assessment of congestive liver dysfunction using technetium-99 m-galactosyl human serum albumin liver scintigraphy in patients with severe valvular heart disease[J]. Surg Today，2007，37（7）:564-569.
[24] YOSHIYUKI T，HIROSHI M. Preoperative evaluation using asialoscintigraphy in patients undergoing cardiac surgery with noncardiac liver cirrhosis[J]. Jpn J Thorac Cardiovasc Surg，2006，54:463-468.
[25] HWANG EH，TAKI J，SHUKE N，et al. Preoperative assessment of residual hepatic functional reserve using 99mTc-DTPA-galactosyl-human serum albumin dynamic SPECT[J]. J Nucl Med，1999，10（40）:1644-1651.
[26] 毛一雷，张涛，桑新亭，等. 应用单光子发射型计算机断层现象评价剩余肝功能的动物实验研究[J]. 中华外科杂志，2007，45（9）：609-612.
[27] 杜顺达，毛一雷，李方，等. 二乙基乙酰苯胺亚氨二醋酸三维现象在肝切除术前肝功能评估中的应用[J]. 中国医学科学院学报，2008，30（4）：409-414.
[28] SUGAHARA K，TOGASHI H，TAKASHI K，et al. Separate analysis of asialoglycoprotein receptorsin the right and left hepatic lobes using 99mTc-GSA SPECT[J]. Hepatology，2003，38（6）:1401-1409.
[29] 廖锦元，黄仲奎，龙莉玲，等. 16层螺旋CT体积测量评估肝硬化肝叶大小的价值[J]. 临床放射杂志，2006，25（5）：425-428.
[30] DE-GRAAF W，VAN LIENDEN KP. （99m）Tc-mebrofenin hepatobiliary scintigraphy with SPECT for the assessment of hepatic function and liver functional volume before partial hepatectomy[J]. J Nucl Med，2010，51（2）:229-36.

单光子发射型计算机断层显像在肝脏储备功能评估中的应用

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐

Metrics

本文评价