实用肝脏病杂志 ›› 2011, Vol. 14 ›› Issue (1): 45-46.doi: 10.3969/j.issn.1672-5069.2011.01.017

• 论著 • 上一篇    下一篇

85例老年药物性肝炎患者临床分析

马琳,刘波   

  1. 230001 合肥市 安徽省政府机关医院(马琳);解放军第105医院感染病科(刘波)
  • 收稿日期:2010-12-02 出版日期:2011-02-10 发布日期:2016-04-15
  • 作者简介:马琳 女,49岁,主治医师

Clinical analysis of 85 elderly patients with drug-induced liver disease

MA Lin,LIU Bo   

  1. The Hospital of AnHui Provincial Government,HeFei 230001
  • Received:2010-12-02 Online:2011-02-10 Published:2016-04-15

摘要: 目的 分析老年人药物性肝炎的临床特点、药物种类及防治原则。方法 对85例老年和87例非老年药物性肝炎患者进行回顾性临床对照分析。结果 在老年药物性肝炎患者,由中(成)草药引起的42例(49.4%),抗生素28例(32.9%),抗结核药7例(8.2%),其他8例(9.4%);肝细胞型38例(44.5%),胆汁淤积型34例(40.0%),混合型13例(15.3%),死亡4例(4.7%);在非老年患者,抗结核药38例(43.7%),抗生素26例(29.9%),中(成)草药15 例(17.2%),其他7例(8.0%);肝细胞型58例(66.7%),胆汁淤积型18例(20.7%),混合型11例(12.6%),无一例死亡。结论 中草药和抗生素是引起老年人药物性肝损害的常见药物。应用中草药和抗生素的老年人应定期检测肝功能。

关键词: 药物性肝炎, 老年人, 临床特点

Abstract: Objective To investigate the clinical characteristics in elderly patients with drug-induced liver injury. Methods 85 elderly and 87 non-elderly patients with drug-induced liver injury were retrospectively studied. Results The top three drugs in elderly patients were Chinese herbal medicine(49.4%),antibiotics(32.9%)and antituberculous agents(8.2%);The cholestasis was found in 40.0% of elderly patients,while only 20.7% in non-elderly patients. Conclusion The Chinese herbal medicine and antibiotics are common agents causing elderly hepatic injury.

Key words: Drug-induced liver disease, Elderly, Clinical feature