HGF及其受体c-met在肝衰竭与部分肝切除模型中表达差异性研究*

doi:10.3969/j.issn.1672-5069.2011.06.001

Abstract

Abstract: Objective To study hepatic growth factor（HGF）and c-met expressions in rat models with liver failure and partial hepatectomy.Methods Liver failure induced by intraperitoneal injection of LPS/D-GalN and by 70% partial hepatectomy was established，and healthy rats served as controls.The level of serum HGF was detected by ELISA assay and c-met gene expression were detected by real-time PCR and Western-bloting.Results Compared with the control group，the serum HGF level and its receptor c-met were significantly elevated in rats with partial hepatectomy，however，the serum HGF level increased with c-met expression significantly reduced in rats with liver failure.Conclusion The compromised hepatic c-met expression might be essential for defects in HGF-mediated liver regeneration in rats with liver failure.

Key words: Liver failure, Liver regeneration, c-met, Hepatic growth factor

ZHU Chuanlong，LI Yuwen，LI Wenting，et al.. Hepatic growth foctor and its receptor c-met expressions in rat models with liver failure and partial hepatectomy[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2011, 14(6): 401-403.

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Hepatic growth foctor and its receptor c-met expressions in rat models with liver failure and partial hepatectomy

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