Abstract: Objective The aim of this study was to investigate prevalence, pathogens distribution and risk factors of multi-drug resistant (MDR) bacteria infection in patients with hepatitis B-induced liver cirrhosis (LC). Methods A total of 1085 consecutive patients with hepatitis B-induced LC were admitted to our hospital between January 2021 and December 2024, clinical materials were collected, and incidence of bacterial infection, distribution of pathogens and impacting risk factors were statistically analyzed. Results Of 1085 patients with LC, incidence of bacterial infection was 28.9% and 381 strains of pathogens, including 233 (61.2%) strains of Gram-negative bacteria and 148 (38.8%) strains of Gram-positive bacteria, were separated from the 314 cases; resistance rate of Escherichia Coli to ciprofloxacin was 74.2%, resistance rate of Pseudomonas Aeruginosa to ciprofloxacin was 74.2%, resistance rate of Staphylococcus to ampicillin was 87.8%, and resistance rate of Enterococcus Faecalis to erythromycin was 71.1%; MDR infection was found in 182 cases(58.0%) out of the 314 patients with bacterial infection, long periods of hospital stay, percentages of Child-Pugh class C, repeatedly antibiotic administration within 90 days, invasive manipulation, concomitant diabetes and complicated gastrointestinal bleeding in patients with MDR infection were significantly higher than in those without, and all these parameters were independent risk factors(P＜0.05) for MDR infection. Conclusion Patients with hepatitis B-induced LC have a tendency of bacteria infection, and those with deteriorated liver functions are even more susceptible to MDR infections, which should be carefully managed for prevention and treatment.

Key words: Liver cirrhosis, Pathogen distribution, Multi-drug resistant bacteria infection, Risk factors